Evidence map›Paper›PMID 38060451›Full record

ArticleCell reports2023

CD62L expression marks a functionally distinct subset of memory B cells.

Christopher H Hanson, Brittany Henry, Pradhnesh Andhare, Frank J Lin, Haley Pak, Jackson S Turner, Lucas J Adams, Tom Liu, Daved H Fremont, Ali H Ellebedy and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Polarization of the memory B-cell response.Journal of leukocyte biology · 2025
    Review
  5. Interleukin-1 signaling and CD4Frontiers in immunology · 2025
    Article
  6. In Vivo CRISPR/Cas9-Mediated Gene Ablation in Murine B Cells.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christopher H HansonDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Brittany HenryDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Pradhnesh AndhareDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Frank J LinDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Haley PakDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jackson S TurnerDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Lucas J AdamsDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Tom LiuDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Daved H FremontDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA.
Ali H EllebedyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO, USA.
Brian J LaidlawDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: brian.laidlaw@wustl.edu.
Washington University in St. Louis · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
IPP: AUTOIMMUNE DISEASES STATISTICAL AND CLINICAL COORDINATING CENTER (ADSCCC)75N93022C00003 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI MILLIN, CHRISTINA · 2022 to 2025
$32.1M
COVID Supplement B Cell Epitope Discovery and Mechanisms of Antibody Protection.75N93019C00062 · NIAID · WASHINGTON UNIVERSITY · PI FREMONT, DAVED · 2019 to 2023
$11.7M
DYNAMICS AND EVOLUTION OF IMMUNE RESPONSES TO INFLUENZA VIRUSESU01AI150747 · NIAID · EMORY UNIVERSITY · PI AHMED, RAFI, ANTIA, RUSTOM NOSHIR · 2020 to 2024
$5.9M
Programming Durable Immune Responses To VaccinationU01AI141990 · NIAID · WASHINGTON UNIVERSITY · PI Ali Hassan Ellebedy · 2019 to 2026
$5.3M
Enhancing the antiviral memory B cell responseDP2AI169978 · NIAID · WASHINGTON UNIVERSITY · PI LAIDLAW, BRIAN · 2021 to 2024
$2.2M
Lung-resident memory B cell development and function following influenza virus infectionK22AI153015 · NIAID · WASHINGTON UNIVERSITY · PI LAIDLAW, BRIAN · 2020 to 2021
$270k
NCATS NIH HHS UL1 TR002345NIAID NIH HHS 75N93019C00051NIAID NIH HHS 75N93019C00062NIAID NIH HHS 75N93022C00003NIAID NIH HHS DP2 AI169978NIAID NIH HHS HHSN272201400006CNIAID NIH HHS HHSN272201400008CNIAID NIH HHS K22 AI153015NIAID NIH HHS U01 AI141990NIAID NIH HHS U01 AI150747NIGMS NIH HHS T32 GM007200
6 · The paper itself

Abstract

The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L

Indexed as

Memory B CellsT-Lymphocyte SubsetsAnimalsAntigensHumansImmunologic MemoryL-SelectinLymphocyte ActivationMiceVaccinationAntigensL-SelectinSELL protein, humanSell protein, mouseB cellsCP: Immunologyhumoral immunityimmunological memory

Identifiers

PMID38060451
PMCPMC10842417
OpenAlexW4389331704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.