Evidence map›Paper›PMID 38060446›Full record

ArticleCell reports2023

FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.

Wendy Leung, Ryan M Baxley, Emma Traband, Ya-Chu Chang, Colette B Rogers, Liangjun Wang, Wesley Durrett, Kendall S Bromley, Lidia Fiedorowicz, Tanay Thakar and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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  11. Ubiquitin and SUMO pathways in DNA replication and replication-coupled repair.Critical reviews in biochemistry and molecular biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Wendy LeungDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Ryan M BaxleyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Emma TrabandDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Ya-Chu ChangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Colette B RogersDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Liangjun WangDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Wesley DurrettDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Kendall S BromleyDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903, USA.
Lidia FiedorowiczDepartment of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903, USA.
Tanay ThakarDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Anika TellaDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Alexandra SobeckInstitute for Human Genetics, Biocenter, University of Würzburg, Würzburg, Germany.
Eric A HendricksonDepartment of Medicine, University of Virginia, Charlottesville, VA 22903, USA.
George-Lucian MoldovanDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Naoko ShimaDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: shima023@umn.edu.
Anja-Katrin BielinskyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22903, USA. Electronic address: azu3jn@virginia.edu.
University of Minnesota · USUniversity of Virginia · USPennsylvania State University · USUniversity of Würzburg · DE

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
TRAINING GRANT IN MICROBIOLOGY/CANCER RESEARCHT32CA009138 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Scott M. Dehm · 1985 to 2026
$11.3M
The role of DNA damage tolerance pathways in human cellsR01GM134681 · NIGMS · UNIVERSITY OF VIRGINIA · PI George Lucian Moldovan, Claudia M Nicolae · 2019 to 2026
$3.0M
Mechanistic insight into genome stability pathwaysR35GM141805 · NIGMS · UNIVERSITY OF VIRGINIA · PI Anja-Katrin Bielinsky · 2021 to 2026
$2.9M
POLQ- and CtIP-regulated telomere fusions and translocations are involved in early events in carcinogenesisR01CA266524 · NCI · UNIVERSITY OF VIRGINIA · PI HENDRICKSON, ERIC A · 2022 to 2025
$2.5M
Genetic mechanisms of Mitotic DNA synthesis in mammalian cellsR01GM138833 · NIGMS · UNIVERSITY OF MINNESOTA · PI SHIMA, NAOKO · 2020 to 2023
$1.2M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA266524NCI NIH HHS T32 CA009138NIGMS NIH HHS R01 GM134681NIGMS NIH HHS R01 GM138833NIGMS NIH HHS R35 GM141805
6 · The paper itself

Abstract

Ubiquitination of proliferating cell nuclear antigen (PCNA) at lysine 164 (K164) activates DNA damage tolerance pathways. Currently, we lack a comprehensive understanding of how PCNA K164 ubiquitination promotes genome stability. To evaluate this, we generated stable cell lines expressing PCNA

Indexed as

DNA RepairFanconi Anemia Complementation Group D2 ProteinDNADNA DamageDNA ReplicationGenomic InstabilityHumansProliferating Cell Nuclear AntigenUbiquitinationDNAFANCD2 protein, humanFanconi Anemia Complementation Group D2 ProteinPCNA protein, humanProliferating Cell Nuclear AntigenCP: Molecular biologyFANCD2MiDASPCNAreplication stressubiquitination

Identifiers

PMID38060446
PMCPMC10842461
OpenAlexW4389331385

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.