Evidence map›Paper›PMID 38060410›Full record

ArticleInhalation toxicology2023

Adjuvant effect of inhaled particulate matter containing free radicals following house-dust mite induction of asthma in mice.

Alexandra Noël, Ashlyn C Harmon, Balamurugan Subramanian, Zakia Perveen, Ankit Aryal, Kelsey Legendre, Hasan Zaman, Daniel B Paulsen, Kurt J Varner, Tammy R Dugas and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inhalation toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alexandra NoëlDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Ashlyn C HarmonDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Balamurugan SubramanianDepartments of Environmental Sciences, Louisiana State University, Baton Rouge, LA, USA.
Zakia PerveenDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Ankit AryalDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Kelsey LegendreDepartments of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, USA.
Hasan ZamanDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Daniel B PaulsenDepartments of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, USA.
Kurt J VarnerDepartment of Pharmacology and Experimental Therapeutics, LSU Health Sciences Center, New Orleans, LA, USA.
Tammy R DugasDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Arthur L PennDepartments of Comparative Biomedical Sciences, Louisiana State University, Baton Rouge, LA, USA.
Louisiana State University · USIo Therapeutics (United States) · US

Funding

Role of microbiota in increased influenza severity due to particulate matter exposureP42ES013648 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI MERCANTE, DONALD E · 2009 to 2024
$27.6M
The role of the endothelium in vascular response to airborne PM.R21ES030062 · NIEHS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI DUGAS, TAMMY R · 2019 to 2020
$415k
NIEHS NIH HHS P42 ES013648NIEHS NIH HHS R21 ES030062
6 · The paper itself

Abstract

introductionExposures to particulate matter (PM) from combustion sources can exacerbate preexisting asthma. However, the cellular and molecular mechanisms by which PM promotes the exacerbation of asthma remain elusive. We used a house dust mite (HDM)-induced mouse model of asthma to test the hypothesis that inhaled DCB230, which are PM containing environmentally persistent free radicals (EPFRs), will aggravate asthmatic responses.

methodsGroups of 8-10-week-old C57BL/6 male mice were exposed to either air or DCB230 aerosols at a concentration of 1.5 mg/m

resultsAerosolized DCB230 particles formed small aggregates (30-150 nm). Mice exposed to DCB230 alone showed significantly reduced lung tidal volume, overexpression of the

conclusionOur data indicate that inhaled DCB230 can act as an adjuvant, exacerbating asthma through IL-17-mediated responses in a HDM mouse model.

Indexed as

AsthmaPneumoniaAnimalsDisease Models, AnimalFree RadicalsInflammationInterleukin-17LungMaleMiceMice, Inbred C57BLParticulate MatterPyroglyphidaeFree RadicalsInterleukin-17Particulate Matterair pollutionasthmaEnvironmentally persistent free radicals (EPFRs)inhalationoxidative stressparticulate matter

Identifiers

PMID38060410
PMCPMC10903547
OpenAlexW4389430716

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.