Evidence map›Paper›PMID 38060282›Full record

ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2023

Intravascular laser lithotripsy for calcium fracture in human coronary arteries.

Aleksandra B Gruslova, Nitesh Katta, Drew Nolen, Scott Jenney, Deborah Vela, Maximilian Buja, Mehmet Cilingiroglu, Yasamin Seddighi, Hai Chao Han, Thomas E Milner and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Aleksandra B GruslovaDepartment of Medicine, University of Texas Health, San Antonio, TX, USA.
Nitesh KattaBeckman Laser Institute and Medical Clinic, University of California at Irvine, Irvine, CA, USA.
Drew NolenDepartment of Medicine, University of Texas Health, San Antonio, TX, USA.
Scott JenneyBeckman Laser Institute and Medical Clinic, University of California at Irvine, Irvine, CA, USA.
Deborah VelaTexas Heart Institute, Houston, TX, USA.
Maximilian BujaTexas Heart Institute, Houston, TX, USA.
Mehmet CilingirogluDepartment of Medicine, University of Texas Health, San Antonio, TX, USA.
Yasamin SeddighiDepartment of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Hai Chao HanDepartment of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX, USA.
Thomas E MilnerBeckman Laser Institute and Medical Clinic, University of California at Irvine, Irvine, CA, USA.
Marc D FeldmanDepartment of Medicine, University of Texas Health, San Antonio, TX, USA.
The University of Texas Health Science Center at San Antonio · USBeckman Laser Institute and Medical Clinic · USThe University of Texas at San Antonio · US

Funding

Transvenous Optoacoustic-Ultrasound Guided Cold Laser Wire for Crossing Coronary Chronic Total OcclusionR01HL163582 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI FELDMAN, MARC, MILNER, THOMAS E · 2022 to 2025
$2.6M
Metasurface Optical Guidewire for percutaneous coronary intervention (PCI)K99HL173631 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KATTA, NITESH · 2024 to 2025
$257k
NHLBI NIH HHS K99 HL173631NHLBI NIH HHS R01 HL163582
6 · The paper itself

Abstract

backgroundElectrical intravascular lithotripsy (E-IVL) uses shock waves to fracture calcified plaque.

aimsWe aimed to demonstrate the ability of laser IVL (L-IVL) to fracture calcified plaques in ex vivo human coronary arteries and to identify and evaluate the mechanisms for increased vessel compliance.

methodsShock waves were generated by a Ho:YAG (Holmium: yttrium-aluminium-garnet) laser (2 J, 5 Hz) and recorded by a high-speed camera and pressure sensor. Tests were conducted on phantoms and 19 fresh human coronary arteries. Before and after L-IVL, arterial compliance and optical coherence tomography (OCT) pullbacks were recorded, followed by histology. Additionally, microcomputed tomography (micro-CT) and scanning electron microscopy (SEM) were performed. Finite element models (FEM) were utilised to examine the mechanism of L-IVL.

resultsPhantom cracks were obtained using 230 μm and 400 μm fibres with shock-wave pressures of 84±5.0 atm and 62±0.4 atm, respectively. Post-lithotripsy, calcium plaque modifications, including fractures and debonding, were identified by OCT in 78% of the ex vivo calcified arteries (n=19). Histological analysis revealed calcium microfractures (38.7±10.4 μm width) in 57% of the arteries which were not visible by OCT. Calcium microfractures were verified by micro-CT and SEM. The lumen area increased from 2.9±0.4 to 4.3±0.8 mm

conclusionsL-IVL has the capability to increase calcified coronary artery compliance by multiple mechanisms.

Indexed as

Fractures, StressLithotripsy, LaserVascular CalcificationCalciumCoronary VesselsHumansTreatment OutcomeX-Ray MicrotomographyCalcium

Identifiers

PMID38060282
PMCPMC10722992
OpenAlexW4389452535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.