Evidence map›Paper›PMID 38060266›Full record

ArticleBioinformatics (Oxford, England)2023

FunctanSNP: an R package for functional analysis of dense SNP data (with interactions).

Rui Ren, Kuangnan Fang, Qingzhao Zhang, Shuangge Ma

Open access · goldAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 74% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Rui RenDepartment of Biostatistics, Yale School of Public Health, New Haven, CT 06520, United States.
Kuangnan FangDepartment of Statistics and Data Science, Xiamen University, Xiamen 361005, China.
Qingzhao ZhangDepartment of Statistics and Data Science, Xiamen University, Xiamen 361005, China.
Shuangge MaDepartment of Biostatistics, Yale School of Public Health, New Haven, CT 06520, United States.ORCID 0000-0001-9001-4999
Xiamen University · CNYale University · US

Funding

Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung CancerP50CA196530 · NCI · YALE UNIVERSITY · PI Harriet M. Kluger · 2015 to 2026
$31.1M
Novel methods for identifying genetic interactions in cancer prognosisR01CA204120 · NCI · YALE UNIVERSITY · PI Shuangge Ma · 2016 to 2026
$3.5M
Integrated Cancer Modeling: A New DimensionR03CA241699 · NCI · YALE UNIVERSITY · PI MA, SHUANGGE · 2019 to 2020
$168k
NCI NIH HHS P50 CA196530NCI NIH HHS R01 CA204120NCI NIH HHS R03 CA241699
6 · The paper itself

Abstract

summaryDensely measured SNP data are routinely analyzed but face challenges due to its high dimensionality, especially when gene-environment interactions are incorporated. In recent literature, a functional analysis strategy has been developed, which treats dense SNP measurements as a realization of a genetic function and can 'bypass' the dimensionality challenge. However, there is a lack of portable and friendly software, which hinders practical utilization of these functional methods. We fill this knowledge gap and develop the R package FunctanSNP. This comprehensive package encompasses estimation, identification, and visualization tools and has undergone extensive testing using both simulated and real data, confirming its reliability. FunctanSNP can serve as a convenient and reliable tool for analyzing SNP and other densely measured data. AVAILABILITY AND IMPLEMENTATION: The package is available at https://CRAN.R-project.org/package=FunctanSNP.

Indexed as

SoftwareReproducibility of Results

Identifiers

PMID38060266
PMCPMC10723032
OpenAlexW4389426664

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.