ArticleInvestigative ophthalmology & visual science2023
A Model of Progression to Help Identify Macular Damage Due to Glaucoma.
Article in Investigative ophthalmology & visual science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Nicotinamide and Pyruvate in Open-Angle Glaucoma: A Randomized Controlled Trial on Neuroprotection-Design and Methodology.Ophthalmology. GlaucomaTrial
- Detection of Disease Progression Using Widefield Optical Coherence Tomography in the Nonhuman Primate Experimental Glaucoma Model.Translational vision science & technology · 2026Article
- Comparison of Macular Ganglion Cell-Inner Plexiform Layer Thickness and Sectoral Ratio Asymmetry Among Different Glaucoma Types.Diagnostics (Basel, Switzerland) · 2026Article
- A Deep Learning Model Detects Glaucoma Based on an OCT Report, but Where Should the Clinician Look to Identify Glaucomatous Damage?Translational vision science & technology · 2025Article
- The association between asymmetric stress distribution on the lamina cribrosa and glaucoma progression.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Pericentral Scotometry Guided by Standard Perimetry Using Microperimetry in Glaucoma Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- A Pattern-Based OCT Metric for Glaucoma Detection.Translational vision science & technology · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The central macula contains a thick donut shaped region of the ganglion cell layer (GCL) that surrounds the fovea. This region, which is about 12 degrees (3.5 mm) in diameter, is essential for everyday functions such as driving, reading, and face recognition. Here, we describe a model of progression of glaucomatous damage to this GCL donut. This model is based upon assumptions supported by the literature, and it predicts the patterns of glaucomatous damage to the GCL donut, as seen with optical coherence tomography (OCT). After describing the assumptions and predictions of this model, we test the model against data from our laboratory, as well as from the literature. Finally, three uses of the model are illustrated. One, it provides an aid to help clinicians focus on the essential central macula and to alert them to look for other, non-glaucomatous causes, when the GCL damage does not fit the pattern predicted by the model. Second, the patterns of progression predicted by the model suggest alternative end points for clinical trials. Finally, the model provides a heuristic for future research concerning the anatomic basis of glaucomatous damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.