ArticleMethods in molecular biology (Clifton, N.J.)2024
Systems Biology Modeling of Cancer Nonlinear Dynamics.
Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Not unlike the climate or what holds the galaxies and planetary motions together, cancer biology has an intrinsic nonlinear dynamic. In this overview we will outline how to connect temporal measurements of a nonlinear dynamical and unstable complex system, such as cancer, with well-established engineering methods, old and new, that are applied in linear dynamical systems.This proof-of-concept is therapeutically relevant in the development of new means to treat or control human cancer by either adding an appropriate external "damping" or a "forcing" term, or by a "control" actuator such that its nonlinear dynamic is steered to a spiral stably into zero forever as a sink attractor.
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