Evidence map›Paper›PMID 38060158›Full record

ReviewGeroScience2024

The Semmelweis Study: a longitudinal occupational cohort study within the framework of the Semmelweis Caring University Model Program for supporting healthy aging.

Zoltan Ungvari, Adam G Tabák, Roza Adany, György Purebl, Csilla Kaposvári, Vince Fazekas-Pongor, Tamás Csípő, Zsófia Szarvas, Krisztián Horváth, Peter Mukli and 25 more

Open access · hybridAbstract readReview
In one paragraph

Review in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 6 institutions in 6 countries.

Zoltan Ungvari *International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary. Zoltan-Ungvari@ouhsc.edu.ORCID 0000-0002-6035-6039
Adam G Tabák *International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
Roza Adany *International Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
György PureblInstitute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Csilla KaposváriDepartment of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Vince Fazekas-PongorDepartment of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Tamás CsípőInternational Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
Zsófia SzarvasInternational Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
Krisztián HorváthDepartment of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Peter MukliInternational Training Program in Geroscience/Healthy Aging Program, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary.
Piroska BalogInstitute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Robert BodizsInstitute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Peter UjmaInstitute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Adrienne StauderInstitute of Behavioral Sciences, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Daniel W BelskyRobert N. Butler Columbia Aging Center, Columbia University, New York, NY, USA.
Illés KovácsDepartment of Ophthalmology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Andriy YabluchanskiyVascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Andrea B MaierHealthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Mariann MoizsDepartment of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Piroska ÖstlinWHO Regional Office for Europe, Copenhagen, Denmark.
Yongjie YonWHO Regional Office for Europe, Copenhagen, Denmark.
Péter VargaDepartment of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Zoltán VokóCenter for Health Technology Assessment, Semmelweis University, Budapest, Hungary.
Magor PappDepartment of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
István TakácsUCL Brain Sciences, University College London, London, UK.
Barna VásárhelyiDepartment of Laboratory Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Péter TorzsaDepartment of Family Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Péter FerdinandyDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Anna CsiszarVascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Zoltán BenyóDepartment of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Attila J SzabóFirst Department of Pediatrics, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Gabriella DörnyeiDepartment of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary.
Mika KivimäkiUCL Brain Sciences, University College London, London, UK.
Miklos KellermayerDepartment of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Bela MerkelyHeart and Vascular Center, Semmelweis University, Budapest, Hungary.
Semmelweis University · HUUniversity College London · GBUniversity of Oklahoma Health Sciences Center · USWorld Health Organization Regional Office for Europe · DKColumbia University · USNational University of Singapore · SG

Funding

Tracking and Evaluation CoreU54GM104938 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Valerie Williams · 2013 to 2026
$68.2M
Visualizing insulin actions on neuronal metabolism and function using fluorescent biosensorsP20GM125528 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Marisol Castillo-Castrejon · 2019 to 2026
$17.8M
Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOLLY VAN REMMEN · 2015 to 2026
$13.9M
Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
Cerebral microhemorrhages and gait dysfunction in agingR01AG055395 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2017 to 2025
$2.3M
Age-related vascular cognitive impairment: role of endothelial senescenceR01AG068295 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA, UNGVARI, ZOLTAN ISTVAN · 2020 to 2024
$1.8M
The role of IGF-1 signaling in vascular smooth muscle cells in age-related vascular cognitive impairment and dementiaR01AG070915 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CONLEY, SHANNON M · 2021 to 2025
$1.8M
Radiation-induced astrocyte dysfunction and cognitive declineR01NS100782 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI UNGVARI, ZOLTAN ISTVAN · 2018 to 2022
$1.7M
Chemotherapy-induced vascular cognitive impairment: role of endothelial senescenceR01CA255840 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA · 2021 to 2025
$1.6M
Cerebromicrovascular rejuvenation by heterochronic blood exchangeRF1AG072295 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CSISZAR, ANNA, UNGVARI, ZOLTAN ISTVAN · 2021 to 2021
$1.4M
Time-restricted feeding (TRF) for prevention of age-related vascular cognitive impairment and dementiaR03AG070479 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI TARANTINI, STEFANO · 2022 to 2022
$290k
Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1Medical Research Council UK S011676NCI NIH HHS R01 CA255840NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG055395NIA NIH HHS R01 AG056477NIA NIH HHS R01 AG068295NIA NIH HHS R01 AG070915NIA NIH HHS R03 AG070479NIA NIH HHS RF1 AG072295NIGMS NIH HHS P20 GM125528NIGMS NIH HHS U54 GM104938NINDS NIH HHS R01 NS100782Wellcome Trust 221854/Z/20/ZWorld Health Organization 001
6 · The paper itself

Abstract

The Semmelweis Study is a prospective occupational cohort study that seeks to enroll all employees of Semmelweis University (Budapest, Hungary) aged 25 years and older, with a population of 8866 people, 70.5% of whom are women. The study builds on the successful experiences of the Whitehall II study and aims to investigate the complex relationships between lifestyle, environmental, and occupational risk factors, and the development and progression of chronic age-associated diseases. An important goal of the Semmelweis Study is to identify groups of people who are aging unsuccessfully and therefore have an increased risk of developing age-associated diseases. To achieve this, the study takes a multidisciplinary approach, collecting economic, social, psychological, cognitive, health, and biological data. The Semmelweis Study comprises a baseline data collection with open healthcare data linkage, followed by repeated data collection waves every 5 years. Data are collected through computer-assisted self-completed questionnaires, followed by a physical health examination, physiological measurements, and the assessment of biomarkers. This article provides a comprehensive overview of the Semmelweis Study, including its origin, context, objectives, design, relevance, and expected contributions.

Indexed as

Healthy AgingCohort StudiesFemaleHumansHungaryMaleProspective StudiesUniversitiesAge-associated diseasesBiological ageCentral EuropeEpidemiologyHealth Promoting UniversityHealthy agingWorkplace cohort

Identifiers

PMID38060158
PMCPMC10828351
OpenAlexW4389449163

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.