ArticlePharmacoEconomics - open2024
United States Value Set for the Functional Assessment of Cancer Therapy-General Eight Dimensions (FACT-8D), a Cancer-Specific Preference-Based Quality of Life Instrument.
Article in PharmacoEconomics - open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- United Kingdom value set for the functional assessment of cancer therapy eight dimension (FACT-8D) preference-based quality of life instrument.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Cancer-specific or generic preference-based measures in oncology? A validity comparison across six commonly diagnosed cancers.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- What do HTA agencies need for generating health-related quality of life evidence? Findings from a global survey.International journal of technology assessment in health care · 2026Article
- An umbrella review of patient- and carer-reported measures for assessing adult end-of-life care quality outcomes.EClinicalMedicine · 2025Article
- Japanese value set for the Functional Assessment of Cancer Therapy Eight Dimension (FACT-8D) cancer-specific preference-based quality of life instrument.Health and quality of life outcomes · 2025Article
- Validation of the Cancer-Specific Preference-Based Measure EORTC QLU-C10D against the Generic Instruments EQ-5D-5L and SF-6Dv2 in a Prospectively Collected Sample of Patients with Cancer in Austria and France.PharmacoEconomics · 2025Article
- Optimal DCE design for modelling nonlinear time preferences in EQ-5D-5L valuation studies: exploration of data from Denmark and Peru.Health and quality of life outcomes · 2025Article
- Assessing the reliability of a novel cancer-specific multi-attribute utility instrument (FACT-8D) and comparing its validity to EQ-5D-5L in colorectal cancer patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- A comparison of measurement properties between EORTC QLU-C10D and FACT-8D in patients with hematological malignances.Health economics review · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesTo develop a value set reflecting the United States (US) general population's preferences for health states described by the Functional Assessment of Cancer Therapy (FACT) eight-dimensions preference-based multi-attribute utility instrument (FACT-8D), derived from the FACT-General cancer-specific health-related quality-of-life (HRQL) questionnaire.
methodsA US online panel was quota-sampled to achieve a general population sample representative by sex, age (≥ 18 years), race and ethnicity. A discrete choice experiment (DCE) was used to value health states. The valuation task involved choosing between pairs of health states (choice-sets) described by varying levels of the FACT-8D HRQL dimensions and survival (life-years). The DCE included 100 choice-sets; each respondent was randomly allocated 16 choice-sets. Data were analysed using conditional logit regression parameterized to fit the quality-adjusted life-year framework, weighted for sociodemographic variables that were non-representative of the US general population. Preference weights were calculated as the ratio of HRQL-level coefficients to the survival coefficient.
results2562 panel members opted in, 2462 (96%) completed at least one choice-set and 2357 (92%) completed 16 choice-sets. Pain and nausea were associated with the largest utility weights, work and sleep had more moderate utility weights, and sadness, worry and support had the smallest utility weights. Within dimensions, more severe HRQL levels were generally associated with larger weights. A preference-weighting algorithm to estimate US utilities from responses to the FACT-General questionnaire was generated. The worst health state's value was -0.33.
conclusionsThis value set provides US population utilities for health states defined by the FACT-8D for use in evaluating oncology treatments.
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Registered trials
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