Evidence map›Paper›PMID 38060076›Full record

SynthesisBreast cancer research and treatment2024

Association between prediabetes and breast cancer: a comprehensive meta-analysis.

Praneeth Reddy Keesari, Akhil Jain, Narendranath Reddy Ganampet, Guna Sowmya Durga Subhasri, Samuel Edusa, Zainab Muslehuddin, Nyein Wint Yee Theik, Spandana Palisetti, Divya Salibindla, Pritika Singh Manaktala and 1 more

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Breast cancer research and treatment, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 2 countries.

Praneeth Reddy Keesari *Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY, USA.
Akhil Jain *Department of Leukemia, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. akhiljaindr@gmail.com.ORCID http://orcid.org/0000-0001-7298-4246
Narendranath Reddy GanampetDepartment of Medicine, Kamineni Academy of Medical Sciences and Research Center, Hyderabad, India.
Guna Sowmya Durga SubhasriDepartment of Medicine, Kamineni Academy of Medical Sciences and Research Center, Hyderabad, India.
Samuel EdusaDepartment of Internal Medicine, Piedmont Athens Regional, Athens, GA, USA.
Zainab MuslehuddinDepartment of Internal Medicine, Detroit Medical Center, Wayne State University-Sinai Grace Hospital, Detroit, MI, USA.
Nyein Wint Yee TheikDepartment of Internal Medicine, Memorial Healthcare System, Hollywood, FL, USA.
Spandana PalisettiDepartment of Medicine, Jawaharlal Nehru Medical College, Belgaum, Karnataka, India.
Divya SalibindlaUniversity of Cincinnati Medical Center, Cincinnati, OH, USA.
Pritika Singh ManaktalaHospice and Palliative Medicine, Cleveland Clinic Akron General Hospital, Akron, OH, USA.
Rupak DesaiIndependent Researcher, Outcomes Research, Atlanta, GA, USA.
Kamineni Hospitals · INCleveland Clinic · USJawaharlal Nehru Medical College · INMemorial Healthcare System · USOutcomes Research Consortium · USPiedmont Athens Regional · USStaten Island University Hospital · USThe University of Texas MD Anderson Cancer Center · USUniversity of Cincinnati · USWayne State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer accounts for up to 30% of cancer cases in women in the US. Diabetes mellitus has been recognized as a risk factor for breast cancer. Some studies have suggested that prediabetes may also be associated with breast cancer whereas other studies have shown no or an inverse association; thus, we conducted a meta-analysis to assess the risk of breast cancer in prediabetes.

methodsWe searched PubMed/Medline, EMBASE, Google Scholar, and Scopus to identify studies that reported breast cancer risks in patients having prediabetes compared to normoglycemic patients. Binary random-effects model was used to calculate a pooled odds ratio (OR) with 95% confidence intervals. I

resultsWe analyzed 7 studies with 24,586 prediabetic and 224,314 normoglycemic individuals (783 and 5739 breast cancer cases, respectively). Unadjusted odds ratio (OR) for breast cancer was 1.45 (95% CI = 1.14, 1.83); adjusted OR was 1.19 (95% CI = 1.07, 1.34) in prediabetes. Subgroup analysis revealed a higher breast cancer risk in individuals aged less than 60 years (OR = 1.86, 95% CI = 1.39, 2.49) than in those aged 60 years or more (OR = 1.07, 95% CI = 0.97, 1.18). Subgroup analysis by median follow-up length indicated a higher risk of breast cancer for follow-ups of less than or equal to 2 years (OR = 2.34, 95% CI = 1.85, 2.95) than in those of over 10 years (OR = 1.1, 95% CI = 0.99, 1.23) and 6 to 10 years (OR = 1.03, 95% CI = 0.88, 1.21).

conclusionsIn conclusion, individuals with prediabetes have higher risk of developing breast cancer than those with normoglycemia, especially younger prediabetes patients. These individuals may benefit from early identification, monitoring, and interventions to reverse prediabetes.

Indexed as

Breast NeoplasmsDiabetes MellitusPrediabetic StateFemaleHumansRisk AssessmentRisk FactorsBreast cancerHbA1cHyperglycemiaMeta-analysisPrediabetesReview

Identifiers

PMID38060076
OpenAlexW4389439568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.