SynthesisNeuropsychology review2025
The Effects of Transcranial Direct Current Stimulation (tDCS) on the Cognitive Functions: A Systematic Review and Meta-analysis.
Synthesis in Neuropsychology review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Chemotherapy-related cognitive impairment and non-pharmacological interventions targeting the nervous system: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Transcranial direct current stimulation for learning and memory in Parkinson's disease: a systematic review.Frontiers in neuroscience · 2026Pooled it
- A systematic review and meta-analysis of the impact of transcranial direct current stimulation on cognitive function in older adults with cognitive impairments: the influence of dosage parameters.Alzheimer's research & therapy · 2025Pooled it
- Meta-analysis of variance in tDCS effects on response inhibition.Scientific reports · 2024Pooled it
- Network-based transcranial direct current stimulation may improve gait and cognitive function in older adults: a randomized controlled crossover study.BMC geriatrics · 2025Trial
- Effect of HD-tDCS targeting the DLPFC on cognitive ability and flight simulation performance in healthy adults.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Trial
- Effects of transcranial direct current stimulation of the right dorsolateral prefrontal cortex on craving and negative emotion regulation in individuals at risk for problematic pornography use: A double-blind, placebo-controlled study.Journal of behavioral addictions · 2025Trial
- Investigating the effects of brain stimulation on the neural substrates of inhibition in patients with OCD: A simultaneous tDCS - fMRI study.Translational psychiatry · 2025Trial
- Cognitive and neurophysiological effects of bilateral tDCS neuromodulation in patients with minimally conscious state.Scientific reports · 2025Trial
- Information processing speed modulation by electrical brain stimulation in multiple sclerosis: towards individually tailored protocols.Brain communications · 2025Trial
- Repeated prefrontal tDCS for improving mental health and cognitive deficits in multiple sclerosis: a randomized, double-blind, parallel-group study.Journal of translational medicine · 2024Trial
- The underlying mechanisms of tDCS-Based cognitive enhancement in unpredictable task switching: A machine learning-based approach for EEG signal analysis.Neuroimage. Reports · 2026Article
- Effects of single-session transcranial direct current stimulation on response inhibition in stop-signal task performance: A meta-analysis and systematic review.General psychiatry · 2026Article
- Effect of transcranial direct current stimulation on perioperative neurocognitive disorder in elderly patients undergoing abdominal tumour surgery: A randomised controlled trial.European journal of anaesthesiology · 2026Article
- The potential role of transcranial direct current stimulation in experimental ischemic stroke in adult male albino rats.Scientific reports · 2026Article
- [A review of noninvasive brain-computer interfaces combined with transcranial electrical stimulation for neural rehabilitation].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026Review
- Multimodal imaging-based targeting approach for network-level brain stimulation.Frontiers in neuroscience · 2026Article
- Transcranial Direct Current Stimulation (tDCS) in Diabetes: A Focused and Mechanistic Review of Symptom and Function Outcomes.Journal of clinical medicine · 2025Review
- Article
- High-Frequency, Low-Intensity Pulsed Electric Field and N-Acetylcysteine Synergistically Protect SH-SY5Y Cells Against Hydrogen Peroxide-Induced Cell Damage In Vitro.Antioxidants (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have investigated the effect of transcranial direct current stimulation (tDCS) on cognitive functions. However, these studies reported inconsistent results due to differences in experiment design, measurements, and stimulation parameters. Nonetheless, there is a lack of meta-analyses and review studies on tDCS and its impact on cognitive functions, including working memory, inhibition, flexibility, and theory of mind. We performed a systematic review and meta-analysis of tDCS studies published from the earliest available data up to October 2021, including studies reporting the effects of tDCS on cognitive functions in human populations. Therefore, these systematic review and meta-analysis aim to comprehensively analyze the effects of anodal and cathodal tDCS on cognitive functions by investigating 69 articles with a total of 5545 participants. Our study reveals significant anodal tDCS effects on various cognitive functions. Specifically, we observed improvements in working memory reaction time (RT), inhibition RT, flexibility RT, theory of mind RT, working memory accuracy, theory of mind accuracy and flexibility accuracy. Furthermore, our findings demonstrate noteworthy cathodal tDCS effects, enhancing working memory accuracy, inhibition accuracy, flexibility RT, flexibility accuracy, theory of mind RT, and theory of mind accuracy. Notably, regarding the influence of stimulation parameters of tDCS on cognitive functions, the results indicated significant differences across various aspects, including the timing of stimulation (online vs. offline studies), population type (clinical vs. healthy studies), stimulation duration (< 15 min vs. > 15 min), electrical current intensities (1-1.5 m.A vs. > 1.5 m.A), stimulation sites (right frontal vs. left frontal studies), age groups (young vs. older studies), and different cognitive tasks in each cognitive functioning aspect. In conclusion, our results demonstrate that tDCS can effectively enhance cognitive task performance, offering valuable insights into the potential benefits of this method for cognitive improvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.