Evidence map›Paper›PMID 38060041›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2024

Review of the potential pharmacological role of erucic acid: a monounsaturated omega-9 fatty acid.

Imran Kazmi, Muhammad Afzal, Fahad A Al-Abbasi, Shareefa A AlGhamdi, Amira M Alghamdi, Sami I Alzarea, Waleed Hassan Almalki, Abeer S AlGhamdi, Khadijah B Alkinani, Nadeem Sayyed

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
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  4. Effect of PMScientific reports · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Imran KazmiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia. ikazmi@kau.edu.sa.
Muhammad AfzalDepartment of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, P.O. Box 6231, 21442, Jeddah, Saudi Arabia.
Fahad A Al-AbbasiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Shareefa A AlGhamdiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Amira M AlghamdiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Sami I AlzareaDepartment of Pharmacology, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Waleed Hassan AlmalkiDepartment of Pharmacology, College of Pharmacy, Umm Al-Qura University, 21955, Makkah, Saudi Arabia.
Abeer S AlGhamdiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Khadijah B AlkinaniDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Nadeem SayyedSchool of Pharmacy, Glocal University, Saharanpur, 247121, India. snadeem.pharma@gmail.com.
King Abdulaziz University · SABatterjee Medical CollegeGlocal University · INJouf University · SAUmm al-Qura University · SA

Funding

Deanship of Scientific Research at Umm Al-Qura University 224UQU4310387DSR03
6 · The paper itself

Abstract

This comprehensive review aims to provide an overview of the pharmacological properties of erucic acid (EA) and highlight areas that require further research. EA is an omega-9 fatty acid found in certain vegetable oil, such as rapeseed oil has demonstrated favourable effects in rodents, including ameliorating myocardial lipidosis (fat accumulation in the heart muscle), congestive heart disease, hepatic steatosis (fat accumulation in the liver), and memory impairments. These findings have prompted regulatory bodies to establish limits on EA content in food oils. The studies were performed on rodents and led to caution on ingesting the EA at high levels. Moreover, EA is frequently utilized as a nutritional supplement for the treatment of adrenoleukodystrophy, myocardial disease, and memory improvement. The review of the article indicated that EA improves cognitive function, has a part in Huntington's disease, interacts with peroxisome proliferator-activated receptors, inhibits elastase and thrombin, has anti-inflammatory, antioxidant, and anti-tumour properties, and inhibits influenza A virus. This article elucidates the pharmacological effects of EA, an omega-9 fatty acid.

Indexed as

Erucic AcidsAnimalsHumanserucic acidErucic AcidsAntioxidantErucic acidMemoryOmega-9 fatty acidPharmacologyPPAR-δ

Identifiers

PMID38060041
OpenAlexW4389452195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.