Evidence map›Paper›PMID 38059674›Full record

ArticleProtein science : a publication of the Protein Society2024

Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N-terminal domain.

Rob Geens, Jessica Stanisich, Olivier Beyens, Stijn D'Hondt, Jean-Michel Thiberge, Amber Ryckebosch, Anke De Groot, Stefan Magez, Didier Vertommen, Rogerio Amino and 4 more

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rob GeensLaboratory of Medical Biochemistry (LMB), University of Antwerp, Antwerp, Belgium.
Jessica StanisichCellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Olivier BeyensLaboratory of Medicinal Chemistry (UAMC), University of Antwerp, Antwerp, Belgium.
Stijn D'HondtLaboratory of Medicinal Chemistry (UAMC), University of Antwerp, Antwerp, Belgium.
Jean-Michel ThibergeUnit of Malaria Infection & Immunity, Institut Pasteur, Paris, France.
Amber RyckeboschLaboratory of Medical Biochemistry (LMB), University of Antwerp, Antwerp, Belgium.
Anke De GrootLaboratory of Medical Biochemistry (LMB), University of Antwerp, Antwerp, Belgium.
Stefan MagezCellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium.
Didier Vertommende Duve Institute and MASSPROT Platform, UCLouvain, Brussels, Belgium.
Rogerio AminoUnit of Malaria Infection & Immunity, Institut Pasteur, Paris, France.
Hans De WinterLaboratory of Medicinal Chemistry (UAMC), University of Antwerp, Antwerp, Belgium.
Alexander N VolkovStructural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.
Peter TompaStructural Biology Brussels, Vrije Universiteit Brussel, Brussels, Belgium.ORCID 0000-0001-8042-9939
Yann G-J SterckxLaboratory of Medical Biochemistry (LMB), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-7420-0983

Funding

Agence Nationale de la Recherche ANR-10-LABX-62-IBEIDAgence Nationale de la Recherche ANR-19-CE15-0027Fonds Wetenschappelijk Onderzoek 1S04221NUniversiteit Antwerpen
6 · The paper itself

Abstract

The circumsporozoite protein (CSP) is the main surface antigen of the Plasmodium sporozoite (SPZ) and forms the basis of the currently only licensed anti-malarial vaccine (RTS,S/AS01). CSP uniformly coats the SPZ and plays a pivotal role in its immunobiology, in both the insect and the vertebrate hosts. Although CSP's N-terminal domain (CSP

Indexed as

AntimalarialsMalaria, FalciparumMalaria VaccinesHumansPlasmodium falciparumProtozoan ProteinsAntimalarialsMalaria VaccinesProtozoan Proteinsbiophysicscircumsporozoite proteinintrinsic disorderPlasmodium falciparumrecombinant protein production and purificationstructural biology

Identifiers

PMID38059674
PMCPMC10749493

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.