ArticlemBio2024
Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered
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Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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0cells of the map it votes in
16citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
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Who cites it
16 citing papers in PubMed, 16 citations in OpenAlex.
- Identification of genetic markers of quinine partial resistance in Plasmodium falciparum.Nature microbiology · 2026Article
- A Multidimensional Analysis of the Bimodal Piperaquine Response inbioRxiv : the preprint server for biology · 2026Article
- Genetic diversity and evolutionary perspectives of Pfcrt in Plasmodium falciparum: insights from Indian and global isolates.Malaria journal · 2026Article
- Gain-of-function PfAAT1 mutations compensate for impaired PfCRT function inResearch square · 2026Article
- Changing genetic profiles ofAntimicrobial agents and chemotherapy · 2026Article
- Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance.Nature communications · 2026Article
- Towards an evolutionary baseline model ofbioRxiv : the preprint server for biology · 2025Article
- Mechanistic snapshots of lipid-linked sugar transfer.Nature communications · 2025Article
- Impact of anionic lipids on the energy landscape of conformational transition in anion exchanger 1 (AE1).Nature communications · 2025Article
- Heme processing in the malaria parasite, Plasmodium falciparum: a time-dependent basal-level analysis.Communications biology · 2025Article
- Frequencies of molecular markers of drug resistance in the context of two different Seasonal Malaria Chemoprevention (SMC) treatment regimens in the Koulikoro health district, Mali.Antimicrobial agents and chemotherapy · 2025Article
- Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity.Cell chemical biology · 2025Article
- The plasmepsin-piperaquine paradox persists in Plasmodium falciparum.PLoS pathogens · 2025Article
- Pf-HaploAtlas: an interactive web app for spatiotemporal analysis of Plasmodium falciparum genes.Bioinformatics (Oxford, England) · 2024Article
- AmBio · 2024Article
- Genetic surveillance shows spread of ACT resistance during period of malaria decline in Vietnam (2018-2020).Frontiers in genetics · 2024Article
Corrections and comments
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Authors and funding
17 authors at 3 institutions in 1 country.
Laura M HagenahDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0001-8258-6823
Satish K DhingraDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Jennifer L Small-SaundersCenter for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0001-6064-2249
Tarrick QahashDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.
Andreas WillemsDepartment of Chemistry, Georgetown University, Washington, DC, USA.
Kyra A SchindlerDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Gabriel W RangelDepartment of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, USA.
Eva Gil-IturbeDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.
Jonathan KimDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, New York, USA.
Emiliya AkhundovaDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, New York, USA.
Tomas YeoDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
John OkomboDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
Filippo ManciaDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, New York, USA.
Matthias QuickDepartment of Psychiatry, Columbia University Irving Medical Center, New York, New York, USA.
Paul D RoepeDepartment of Chemistry, Georgetown University, Washington, DC, USA.
Manuel LlinásDepartment of Chemistry, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-6173-5882
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0001-6753-8938
Columbia University Irving Medical Center · USPennsylvania State University · USGeorgetown University · US
Funding
The Function of Antimalarial Drug Resistance ProteinsR01AI056312 · NIAID · GEORGETOWN UNIVERSITY · PI PAUL D. ROEPE · 2003 to 2026
$7.5MRole of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7MLeveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant MalariaR01AI147628 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock, Filippo Mancia · 2019 to 2026
$5.1MDefining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4MElucidating the molecular basis of piperaquine resistance in Plasmodium falciparumR01AI124678 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2016 to 2026
$4.3MColumbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1MtRNA modification reprogramming in artemisinin-resistant Plasmodium falciparum: An epigenetic driver of resistance?K08AI163497 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SMALL-SAUNDERS, JENNIFER L. · 2021 to 2024
$769kDeciphering the role of Plasmodium falciparum plasmepsin 2/3 amplifications in mutant pfcrt-driven piperaquine resistanceR21AI159558 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2021 to 2022
$446kQuantifying Redox Potentials for Artemisinin Resistant (ARTR) MalariaR21AI168720 · NIAID · GEORGETOWN UNIVERSITY · PI ROEPE, PAUL D. · 2022 to 2023
$420kArtemisinin activation in artemisinin resistant malarial parasitesR21AI146506 · NIAID · GEORGETOWN UNIVERSITY · PI ROEPE, PAUL D. · 2020 to 2021
$420kModeling mutant PfCRT-mediated drug transport to predict the emergence of piperaquine-resistant Plasmodium falciparum malariaF31AI157410 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HAGENAH, LAURA MARIE · 2021 to 2023
$140kNIAID NIH HHS F31 AI157410NIAID NIH HHS K08 AI163497NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI056312NIAID NIH HHS R01 AI124678NIAID NIH HHS R01 AI147628NIAID NIH HHS R21 AI146506NIAID NIH HHS R21 AI159558NIAID NIH HHS R21 AI168720NIAID NIH HHS R37 AI050234NIAID NIH HHS T32 AI106711
Abstract
importanceOur study leverages gene editing techniques in
Indexed as
AntimalarialsMalaria, FalciparumParasitesPiperazinesQuinolinesAnimalsChloroquineDrug ResistanceMutationPlasmodium falciparumProtozoan ProteinsAntimalarialsChloroquinepiperaquinePiperazinesProtozoan ProteinsQuinolinesdrug resistance evolutionfitnessmalariaPfCRTPlasmodium falciparum
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.