Evidence map›Paper›PMID 38059558›Full record

ArticleThe Journal of infectious diseases2024

Potential Impact of Higher-Valency Pneumococcal Conjugate Vaccines Among Adults in Different Localities in Germany.

Mallory K Ellingson, Daniel M Weinberger, Mark van der Linden, Stephanie Perniciaro

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. [Current and new vaccines against pneumococci].Innere Medizin (Heidelberg, Germany) · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mallory K EllingsonDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut.
Daniel M WeinbergerDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut.
Mark van der LindenGerman National Reference Center for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany.
Stephanie PerniciaroDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, Connecticut.ORCID 0000-0002-3146-2182
Yale University · USRWTH Aachen University · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Research Training in Pediatric Infectious DiseasesT32AI007210 · NIAID · YALE UNIVERSITY · PI MURRAY, THOMAS SCOT, SHAPIRO, EUGENE DAVID · 1986 to 2023
$2.6M
Forecasting pneumococcal serotype frequencies to develop adult-specific vaccinesR01AI123208 · NIAID · YALE UNIVERSITY · PI WEINBERGER, DANIEL MARTIN · 2016 to 2019
$2.5M
Merck & Co, IncNational Institute of Allergy and Infectious Diseases R01-AI123208NCATS NIH HHS KL2 TR001862NCATS NIH HHS UL1 TR001863NIAID NIH HHS T32 AI007210NIH HHSPfizer Deutschland GmbHRobert Koch Institute
6 · The paper itself

Abstract

Next-generation pneumococcal conjugate vaccines (PCVs) have been approved for use. The serotype distribution of pneumococcal isolates can vary between regions. To understand the potential impacts of new PCVs, we evaluated trends in invasive pneumococcal disease (IPD) among adults in Germany at a local level using Bayesian hierarchical logistic regression. There was little spatial variation in IPD cases caused by 13-valent PCV serotypes, which dropped from 60% of IPD cases in 2006 to 30% in 2018. More than half of IPD cases in 2018 were attributable to serotypes covered by new PCVs (15-valent and 20-valent PCVs), which suggests they could further reduce the burden of IPD.

Indexed as

Pneumococcal InfectionsPneumococcal VaccinesSerogroupStreptococcus pneumoniaeVaccines, ConjugateAdolescentAdultAgedAged, 80 and overBayes TheoremFemaleGermanyHumansMaleMiddle AgedYoung Adult13-valent pneumococcal vaccinePneumococcal VaccinesVaccines, Conjugateinvasive pneumococcal diseaseIPDpneumococcal disease in adultspneumococcal disease in GermanyStreptococcus pneumoniae

Identifiers

PMID38059558
PMCPMC11175678
OpenAlexW4389452570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.