Evidence map›Paper›PMID 38059322›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2023

Dapagliflozin-entresto protected kidney from renal hypertension via downregulating cell-stress signaling and upregulating SIRT1/PGC-1α/Mfn2-medicated mitochondrial homeostasis.

Sheung-Fat Ko, Chih-Chao Yang, Pei-Hsun Sung, Ben-Chung Cheng, Pei-Lin Shao, Yi-Ling Chen, Hon-Kan Yip

Open access · greenAbstract read
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. The role of SIRT1 in kidney diseases.International urology and nephrology · 2025
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sheung-Fat KoDepartment of Radiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.
Chih-Chao YangDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.
Pei-Hsun SungDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.
Ben-Chung ChengDivision of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.
Pei-Lin ShaoDepartment of Nursing, Asia University, Taichung 41354.
Yi-Ling ChenDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.
Hon-Kan YipDivision of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 88301.ORCID 0000-0002-6305-5717
Kaohsiung Chang Gung Memorial Hospital · TWAsia University · JPChang Gung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study tested whether combined dapagliflozin and entresto would be superior to mere one therapy on protecting the residual renal function and integrity of kidney parenchyma in hypertensive kidney disease (HKD) rat.

Indexed as

AminobutyratesBenzhydryl CompoundsBiphenyl CompoundsGlucosidesHypertension, RenalNephritisSirtuin 1ValsartanAnimalsbcl-2-Associated X ProteinBiomarkersCreatinineCytochromesDrug CombinationsHomeostasisHydrogen PeroxideAminobutyratesbcl-2-Associated X ProteinBenzhydryl CompoundsBiomarkersBiphenyl CompoundsCreatinineCytochromesdapagliflozinDrug CombinationsGlucosidesHydrogen Peroxidesacubitril and valsartan sodium hydrate drug combinationSirtuin 1ValsartanChronic kidney diseasedapagliflozinentrestohypertensionkidney ultrastructurerenal function

Identifiers

PMID38059322
PMCPMC10903247
OpenAlexW4389442670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.