Evidence map›Paper›PMID 38059296›Full record

ArticleAmerican journal of physiology. Renal physiology2024

Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.

Truyen D Pham, Jill W Verlander, Chao Chen, Vladimir Pech, Hailey I Kim, Young Hee Kim, I David Weiner, Ginger L Milne, Roy Zent, Fabian Bock and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Pendrin is upregulated by corticosterone and participates in its pressor response.American journal of physiology. Renal physiology · 2026
    Article
  3. Rac1 promotes proximal tubule kidney repair by coupling the actin cytoskeleton to mitochondrial function.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Intercalated Cell ClC-K2 Channel Contributes to Systemic ClFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Integrins in the kidney - beyond the matrix.Nature reviews. Nephrology · 2025
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Truyen D PhamRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Jill W VerlanderDivision of Nephrology, Hypertension and Renal Transplantation, The University of Florida College of Medicine, Gainesville, Florida, United States.
Chao ChenDivision of Nephrology, Hypertension and Renal Transplantation, The University of Florida College of Medicine, Gainesville, Florida, United States.
Vladimir PechRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Hailey I KimRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
Young Hee KimRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
I David WeinerDivision of Nephrology, Hypertension and Renal Transplantation, The University of Florida College of Medicine, Gainesville, Florida, United States.ORCID 0000-0002-0046-0600
Ginger L MilneDivision of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-3890-151X
Roy ZentDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-2983-8133
Fabian BockDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Dennis BrownProgram in Membrane Biology, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0002-5011-7798
Amity EatonProgram in Membrane Biology, Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States.ORCID 0000-0003-0791-3411
Susan M WallRenal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.ORCID 0000-0003-2786-8849
Emory University · USVanderbilt University Medical Center · USHarvard University · USUniversity of Florida · USVeterans Health Administration · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2000 to 2019
$31.4M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
The Laminin Receptors in Kidney FibrosisR01DK069921 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ROY ZENT · 2005 to 2026
$9.5M
TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
P&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Dennis Brown · 2023 to 2026
$5.4M
Structure and Function of Integrins in the KidneyR01DK088327 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ARNAOUT, M. AMIN · 2010 to 2025
$5.3M
BLRD VA I01 BX002196NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIDDK NIH HHS K08 DK134879NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK058404NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK069921NIDDK NIH HHS R01 DK088327NIDDK NIH HHS R01 DK107798NIDDK NIH HHS R01 DK110375NIDDK NIH HHS R01 DK119793NIDDK NIH HHS R01 DK121848NIDDK NIH HHS R01 DK127589NIDDK NIH HHS T32 DK007540NIDDK NIH HHS U24 DK059637NIH HHS S10 OD021577NIH HHS S10 OD021630
6 · The paper itself

Abstract

Angiotensin II increases apical plasma membrane pendrin abundance and function. This study explored the role of the small GTPase Rac1 in the regulation of pendrin by angiotensin II. To do this, we generated intercalated cell (IC) Rac1 knockout mice and observed that IC Rac1 gene ablation reduced the relative abundance of pendrin in the apical region of intercalated cells in angiotensin II-treated mice but not vehicle-treated mice. Similarly, the Rac1 inhibitor EHT 1864 reduced apical pendrin abundance in angiotensin II-treated mice, through a mechanism that does not require aldosterone. This IC angiotensin II-Rac1 signaling cascade modulates pendrin subcellular distribution without significantly changing actin organization. However, NADPH oxidase inhibition with APX 115 reduced apical pendrin abundance in vivo in angiotensin II-treated mice. Moreover, superoxide dismutase mimetics reduced Cl

Indexed as

Angiotensin IIrac1 GTP-Binding ProteinSulfate TransportersAldosteroneAnimalsMiceMice, KnockoutNADPH OxidasesNeuropeptidesSuperoxidesAldosteroneAngiotensin IINADPH OxidasesNeuropeptidesrac1 GTP-Binding ProteinRac1 protein, mouseSlc26a4 protein, mouseSulfate TransportersSuperoxideschloridehypertensionNADPH oxidasependrinRac1

Identifiers

PMID38059296
PMCPMC11198991
OpenAlexW4389443891

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.