Evidence map›Paper›PMID 38059292›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Cyclooxygenase inhibition does not blunt thermal hyperemia in skeletal muscle of humans.

Rauchelle E Richey, Ysabella I Ruiz, Heidi L Cope, Amy M Moore, Mackenzie A Walsh, Tyson C Garfield, Albert H Olivencia-Yurvati, Steven A Romero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rauchelle E RicheyDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-7090-1782
Ysabella I RuizDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-4701-9943
Heidi L CopeDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0009-0008-9764-8052
Amy M MooreDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Mackenzie A WalshDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Tyson C GarfieldDepartment of Internal Medicine and Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Albert H Olivencia-YurvatiDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.
Steven A RomeroDepartment of Physiology and Anatomy, Human Vascular Physiology Laboratory, University of North Texas Health Science Center, Fort Worth, Texas, United States.ORCID 0000-0002-2014-7806
University of North Texas · US

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Chronic Lower Leg Heating for the Treatment of Hypertension in Older WomenR01AG059314 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI FU, QI, ROMERO, STEVEN A. · 2019 to 2023
$3.3M
American Heart Association-American Stroke Association 958179NIA NIH HHS R01 AG059314NIA NIH HHS T32 AG020494
6 · The paper itself

Abstract

Acute heat exposure increases skeletal muscle blood flow in humans. However, the mechanisms mediating this hyperemic response remain unknown. The cyclooxygenase pathway is active in skeletal muscle, is heat sensitive, and contributes to cutaneous thermal hyperemia in young healthy humans. Therefore, the purpose of this study was to test the hypothesis that cyclooxygenase inhibition would attenuate blood flow in the vastus lateralis muscle during localized heating. Twelve participants (6 women) were studied on two separate occasions:

Indexed as

HyperemiaCyclooxygenase 2FemaleHumansIbuprofenMuscle, SkeletalProstaglandinsRegional Blood FlowVasodilator AgentsCyclooxygenase 2IbuprofenProstaglandinsVasodilator Agentsheat exposuremicrodialysismuscle blood flow

Identifiers

PMID38059292
PMCPMC11191756
OpenAlexW4389451729

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.