Evidence map›Paper›PMID 38058996›Full record

ReviewNeuroImmune pharmacology and therapeutics2023

Developmental outcomes with perinatal exposure (DOPE) to prescription opioids.

Adrian Flores, Nghi M Nguyen, Gurudutt Pendyala

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NeuroImmune pharmacology and therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Adrian FloresDepartment of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE, USA.
Nghi M NguyenDepartment of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE, USA.
Gurudutt PendyalaDepartment of Anesthesiology, University of Nebraska Medical Center (UNMC), Omaha, NE, USA.

Funding

Strategies to define and mitigate the placental and fetal alterations caused by maternal oxycodone exposureR01DA059177 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Lynda Katherine Harris, Gurudutt Pendyala · 2023 to 2026
$3.4M
Extracellular vesicles, meth relapse and sex differencesR01DA046852 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BEVINS, RICK A, PENDYALA, GURUDUTT · 2018 to 2022
$2.4M
High-throughput Integrated Magneto-electrochemical Exosome (HiMEX) platform to identify neurodevelopmental markers associated with pre and postnatal oxycodone exposureR21DA049577 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LEE, HAKHO, PENDYALA, GURUDUTT · 2019 to 2020
$458k
Mechanisms underlying prescription opioid use post social defeat in HIV+ adolescentsR21DA058588 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PENDYALA, GURUDUTT · 2023 to 2024
$455k
NIDA NIH HHS R01 DA046852NIDA NIH HHS R01 DA059177NIDA NIH HHS R21 DA049577NIDA NIH HHS R21 DA058588
6 · The paper itself

Abstract

Researchers have found considerable evidence in the past 20 years that perinatal opioid exposure leads to an increased risk of developmental disorders in offspring that persist into adulthood. The use of opioids to treat pain concerning pregnancy, delivery, and postpartum complications has been rising. As a result, communities have reported a 300-400 % increase in Neonatal Opioid Withdrawal Syndrome (NOWS). NOWS represents the initial stage of several behavioral, phenotypic, and synaptic deficits. This review article summarizes the Developmental Outcomes of Perinatal Exposure (DOPE) to prescription opioids. Moreover, we also seek to connect these findings to clinical research that describes DOPE at multiple stages of life. Since specific mechanisms that underlie DOPE remain unclear, this article aims to provide a framework for conceptualizing across all ages and highlight the implications they may have for longevity.

Indexed as

epidemiologyneurobehaviorperinatalpreclinicalprescription opioids

Identifiers

PMID38058996
PMCPMC10696573

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.