Evidence map›Paper›PMID 38058848›Full record

ArticleAfrican journal of laboratory medicine2023

Role of CTX-M-15 gene in spread of extended-spectrum beta-lactamases among immunocompetent patients in Ghana.

Noah Obeng-Nkrumah, Gloria D Tawiah-Abrokwa, Enid Owusu, Francisca Duah, Daniel Oduro-Mensah, Paul Kwao, Bako Evariste, Appiah-Korang Labi

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Article in African journal of laboratory medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Noah Obeng-NkrumahDepartment of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-1797-822X
Gloria D Tawiah-AbrokwaDepartment of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0003-2594-3956
Enid OwusuDepartment of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0003-1100-5379
Francisca DuahDepartment of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-4922-4916
Daniel Oduro-MensahDepartment of Biochemistry, Cell and Molecular Biology, School of Biological Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0003-4492-2202
Paul KwaoDepartment of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0002-3470-700X
Bako EvaristeTenkodogo University Center, Thomas Sankara University, Ouagadougou, Burkina Faso.ORCID https://orcid.org/0000-0001-8762-7882
Appiah-Korang LabiDepartment of Medical Microbiology, University of Ghana Medical School, University of Ghana, Accra, Ghana.ORCID https://orcid.org/0000-0001-7276-7057

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with faecal carriage of extended-spectrum beta-lactamases (ESBL)-producing Enterobacterales serve as reservoirs and sources of dissemination and infection. Objective: This report examined immunocompetent patients for faecal carriage of ESBL-producing Enterobacterales in a district care hospital setting in Ghana. Methods: Between March 2019 and May 2020, cross-sectional sampling was performed to enrol patients and conduct questionnaire-structured interviews for factors that predispose patients to ESBL faecal carriage. Faecal samples from study patients were quantified for ESBL-producing Enterobacterales. The ESBL genes were characterised by polymerase chain reaction and sequencing. Results: The overall proportion of ESBL faecal carriage was 35.5% ( Conclusion: The study found that CTX-M-15-producing isolates were the predominant faecal Enterobacterales, and that further investigations are needed to determine the reasons behind this dominance. What this study adds: The CTX-M-15-producing isolates dominance in this study shows the misuse and abuse of antibiotics in an African medical facility and indicates the potential role of immunity in controlling ESBL spread, which is to be investigated further.

Indexed as

Enterobacteralesextended-spectrum beta-lactamasesfaecal carriageGhanainpatientprevalence

Identifiers

PMID38058848
PMCPMC10696557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.