ArticleArchives of medical science : AMS2023
Down-regulation of PM20D1 is associated with clinical outcomes and prognosis of pregnant patients with diabetes mellitus.
Article in Archives of medical science : AMS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 4 citations in OpenAlex.
- Epigenetic and immunological alterations in umbilical cord blood of overweight/obese women with gestational diabetes mellitus: insights into DNA methylation signatures and immune cell dysregulation.BMC pregnancy and childbirth · 2026Article
- Development and validation of a nomogram prediction model for delayed cerebral edema after intracerebral hemorrhage based on serum inflammatory markers and hemodynamics.Archives of medical science : AMS · 2026Article
- The rare glucose response curve during oral glucose tolerance tests in pregnant Chinese women and its association with preterm birth.Archives of medical science : AMS · 2026Article
- Association between the glucose pattern in oral glucose tolerance test and adverse pregnancy outcomes among non-diabetic women.Journal of health, population, and nutrition · 2025Article
- Serum PM20D1 levels are associated with nutritional status and inflammatory factors in gastric cancer patients undergoing early enteral nutrition.Open medicine (Warsaw, Poland) · 2025Article
- Serum PM20D1 levels in patients with idiopathic pulmonary arterial hypertension and its clinical significance.BMC cardiovascular disorders · 2024Observational
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
Introduction: The present study aimed to investigate the role of peptidase M20 domain containing 1 (PM20D1) in gestational diabetes mellitus (GDM). Material and methods: This observational study included 189 cases of GDM patients who came to our department between March 2018 and December 2019. Additionally, 100 healthy pregnant individuals who came to physical examination were included as healthy controls during the same period. Western blotting was used to determine the expression of PM20D1 at gestational age 24-28 weeks and gestational age 37-40 weeks. Serum inflammatory factors of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, as well as leptin and adiponectin, were all measured by ELISA. The GDM related indices were also measured. Results: The expression of PM20D1 was markedly decreased in GDM patients compared with the healthy controls. Patients in the third trimester of pregnancy (gestational age 37-40 weeks) showed significantly lower expression of PM20D1 than patients in the second trimester of pregnancy (gestational age 24-28 weeks). Serum levels of CRP, IL-1β, IL-6, TNF-α and leptin were remarkably higher and levels of adiponectin were markedly lower in GDM patients at both the second and third trimester of pregnancy. Also, levels of CRP, IL-1β, IL-6, TNF-α and leptin in GDM patients were the highest at the third trimester of pregnancy. Pearson's analysis showed that PM20D1 was negatively correlated with IL-1β, IL-6 and leptin and was positively correlated with adiponectin. At the second trimester of pregnancy, patients with lower expression of PM20D1 showed remarkably higher levels of HOMA-IR, fasting insulin, FBG, OGTT-1hPG, OGTT-2hPG, TG and LDL-C, and showed markedly lower levels of HDL-C. Down-regulated PM20D1 predicted poor pregnancy outcomes. Conclusions: Reduced PM20D1 was associated with patients' clinical outcomes and pregnancy outcomes in GDM.
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