Evidence map›Paper›PMID 38058621›Full record

ArticleHeliyon2023

A potential mechanism of miana (

Ade Rifka Junita, Firdaus Hamid, Budu Budu, Rosdiana Natzir, Yusmina Hala, Gemini Alam, Rosana Agus, Burhanuddin Bahar, Ahmad Syukri, Muhammad Reza Primaguna and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Ade Rifka JunitaPostgraduate School, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Firdaus HamidDepartment of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Budu BuduDepartment of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Rosdiana NatzirDepartment of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Yusmina HalaDepartment of Biology, Faculty of Sciences, State University of Makassar, Makassar, Indonesia.
Gemini AlamDepartment of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
Rosana AgusDepartment of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
Burhanuddin BaharDepartment of Biostatistic, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Ahmad SyukriPostgraduate School, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Muhammad Reza PrimagunaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Ressy DwiyantiDepartment of Medical Microbiology, Faculty of Medicine, Tadulako University, Palu, Indonesia.
Andini FebriantiDepartment of Forensic and Medicolegal, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Muhammad SabirDepartment of Medical Microbiology, Faculty of Medicine, Tadulako University, Palu, Indonesia.
Azhar AzharDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Mochammad HattaMolecular Biology and Immunology Laboratory, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Hasanuddin University · IDTadulako University · IDState University of Makassar · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To prove the effect of Miana (M), Quercetin (Q), and the combination as an anti-inflammatory agent and Cefixime (C) as an antibiotic in Balb/c mice infected with Methods: A cohort study on male Balb/c mice with subjects consisted of 8 groups with 5 each group by administration of M, Q, M + Q, M + C, Q + C, M + Q + C, C only and sterile distilled water group as negative control. The statistical significance of the difference group was defined as Results: Decreased mRNA expression of NF-κB, NF-κB protein levels, and bacterial load after administration of M + C, Q + C, or M + Q + C showed significant differences when compared to the negative control. The decline in NF-κB was stronger when M + Q + C was given compared to M, Q, M + Q, or C only. Conclusion: The effects of NF-κB suppression appear to be the same between the administration of M, Q and the M + Q when C added. However, the suppression of NF-κB was not significant without adding C.

Indexed as

AntibacterialAnti-inflammationMiana (Coleus scutellariodes)Nuclear factor-kappa B (NF-κB)QuercetinSalmonella enterica serovar typhi (S. typhi)

Identifiers

PMID38058621
PMCPMC10696054
OpenAlexW4388673169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.