ArticleHeliyon2023
Comparative study of antioxidant and antimicrobial activity of berberine-derived Schiff bases, nitro-berberine and amino-berberine.
Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 27 citations in OpenAlex.
- Berberine and Berberine-Derived Compounds as Promising Weapons AgainstPharmaceuticals (Basel, Switzerland) · 2026Review
- A recyclable dendrimeric Ni nanocatalyst anchored on magnetic nanoparticles for the green reduction of nitroarene pollutants and one-pot synthesis of imines.Scientific reports · 2026Article
- Synergistic effect of the rifaximin-berberine combination againstBiomolecules & biomedicine · 2026Article
- An updated overview of alkaloids for the prevention and treatment of metabolic dysfunction-associated steatotic liver disease.Frontiers in pharmacology · 2026Review
- Recent Advances in Synthetic Isoquinoline-Based Derivatives in Drug Design.Molecules (Basel, Switzerland) · 2025Review
- 3D tumor cultures for drug resistance and screening development in clinical applications.Molecular cancer · 2025Review
- Network Pharmacology andCurrent computer-aided drug design · 2025Article
- Current View on Major Natural Compounds Endowed with Antibacterial and Antiviral Effects.Antibiotics (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent years, the scientific community has focused on traditional natural products and their potential therapeutic benefits. Berberine is a plant-derived isoquinoline alkaloid with a variety of biological properties and identified as a promising pharmacophore for discovering new therapeutic agents against various diseases. However, unfavorable pharmacokinetic properties of berberine have limited its clinical application so much that researchers pursue its structure modification to overcome this problem. This study focuses on the synthesis of new berberine derivatives to improve its antioxidant and antimicrobial potentials, which were characterized using CHNO and NMR instruments. Berberine extracted from barberry root was nitrated, reduced to amine and condensed with benzaldehyde derivatives to produce berberine-based Schiff bases. The H atom donating ability of all compounds was measured against DPPH free radicals, with IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.