Evidence map›Paper›PMID 38058416›Full record

ArticleAfrican journal of infectious diseases2024

IMPACT OF COVID-19 ON PEOPLE LIVING WITH HIV IN MADAGASCAR: A SARS-COV2 SERO-PREVALENCE SURVEY.

Rakotomalala Fetra Angelot, Randriarimanana Santatriniaina Dauphin, Randriamananjara Hajanirina Nathanaella, Babin François Xavier, Randriantsara Haja, Rasamoelina Tahinamandranto, Rakoto Danielle Aurore Doll, Samison Luc Hervé, Ayouba Ahidjo, Nerrienet Eric

Open access · diamondAbstract read
In one paragraph

Article in African journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 77% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Rakotomalala Fetra AngelotCentre d'Infectiologie Charles Mérieux, Madagascar.
Randriarimanana Santatriniaina DauphinCentre d'Infectiologie Charles Mérieux, Madagascar.
Randriamananjara Hajanirina NathanaellaCentre d'Infectiologie Charles Mérieux, Madagascar.
Babin François XavierFondation Mérieux Lyon, France.
Randriantsara HajaProgramme National de Lutte contre les IST-SIDA, Madagascar.
Rasamoelina TahinamandrantoCentre d'Infectiologie Charles Mérieux, Madagascar.
Rakoto Danielle Aurore DollEcole Doctorale Sciences de la Vie et de l'Environnement Université d'Antananarivo, Madagascar.
Samison Luc HervéCentre d'Infectiologie Charles Mérieux, Madagascar.
Ayouba AhidjoRecherches Translationnelles sur le VIH et les Maladies Infectieuses (TransVIHMI), Université de Montpellier, IRD, INSERM, France.
Nerrienet EricFondation Mérieux Lyon, France.
Fondation Mérieux · FRUniversité de Montpellier · FRUniversity of Antananarivo · MG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In Madagascar, no study has reported the impact of COVID-19 on people living with HIV (PLHIV). The present work aimed to analyze the seroprevalence of SARS-CoV-2 in Malagasy PLHIV before and during the three waves of COVID-19 pandemic.This is a retrospective study. Materials and Methods: We conducted a retrospective serological survey in PLHIV followed up for HIV viral load (VL) monitoring at the Centre d'Infectiologie Charles Mérieux Madagascar (CICM) between June 2019 and April 2022. The presence of IgM and/or IgG antibodies against SARS-CoV-2 nucleoprotein was detected using a rapid diagnostic test (COVID-PRESTO®). Results: A seroprevalence of 2.5% was found in the 877 patients tested before March 2020, compared to 25.4% (512/2,011) between March 2020 and April 2022. This seroprevalence was 21.7%, 22.3% and 60.1% after the first, second and third waves of COVID-19, respectively. We observed a marginally significant difference (p = 0.043) in SARS-CoV-2 seroprevalence between patients on highly active antiretroviral therapy (HAART) (27.5%) and those who were not (23.7%). No statistically significant difference was observed between PLHIV with undetectable HIV VL (27.4%) and the different detectable VL categories (p>0.05). Conclusions: Our data show the presence of antibodies to SARS-CoV-2 among PLHIV as early as December 2019 in Madagascar. At least 25.4% (512/2,011) of Malagasy PLHIV have been in contact with SARS-CoV-2 since March 2020. There is no significant relation between HIV-1 VL and SARS-CoV-2 seroprevalence. Additional studies with more robust assays in the general population are needed for a detailed knowledge of SARS-CoV-2 impact in Madagascar.

Indexed as

MadagascarPLHIVSARS-CoV-2Seroprevalence

Identifiers

PMID38058416
PMCPMC10696651
OpenAlexW4389087108

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.