Evidence map›Paper›PMID 38058218›Full record

ArticleFEBS letters2024

Intrinsic disorder of a nucleoplasmin-like histone chaperone specifies its discrete nuclear and nucleolar functions.

Courtney M Gauthier, Josey LeGallais, Neda Savic, Sarah Moradi-Fard, Arden Grew, Martin Loe, Baran Kirlikaya, Jennifer Cobb, Christopher J Nelson

Open access · bronzeAbstract readLetterComment
PubMed Publisher
In one paragraph

Article in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Courtney M GauthierDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Josey LeGallaisDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Neda SavicDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Sarah Moradi-FardDepartments of Biochemistry & Molecular Biology and Oncology, Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Canada.
Arden GrewDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Martin LoeDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Baran KirlikayaDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Jennifer CobbDepartment of Biochemistry and Microbiology, University of Victoria, Canada.
Christopher J NelsonDepartment of Biochemistry and Microbiology, University of Victoria, Canada.ORCID 0000-0001-5011-7512
University of Victoria · CAUniversity of Calgary · CA

Funding

Canadian Institutes of Health Research (CIHR) MOP-137062Canadian Institutes of Health Research (CIHR) MOP-82736Natural Sciences and Engineering Research Council of Canada 371680Natural Sciences and Engineering Research Council of Canada 418122Natural Sciences and Engineering Research Council of Canada 477782
6 · The paper itself

Abstract

Nucleoplasmin (NPM) histone chaperones regulate distinct processes in the nucleus and nucleolus. While intrinsically disordered regions (IDRs) are hallmarks of NPMs, it is not clear whether all NPM functions require these unstructured features. We assessed the importance of IDRs in a yeast NPM-like protein and found that regulation of rDNA copy number and genetic interactions with the nucleolar RNA surveillance machinery require the highly conserved FKBP prolyl isomerase domain, but not the NPM domain or IDRs. By contrast, transcriptional repression in the nucleus requires IDRs. Furthermore, multiple lysines in polyacidic serine/lysine motifs of IDRs are required for both lysine polyphosphorylation and NPM-mediated transcriptional repression. These results demonstrate that this NPM-like protein relies on IDRs only for some of its chromatin-related functions.

Indexed as

Histone ChaperonesLysineCell NucleolusChromatinNucleoplasminsSaccharomyces cerevisiaeChromatinHistone ChaperonesLysineNucleoplasminschromatinFKBP prolyl isomeraseintrinsic disordernucleoplasminnucleus/nucleolusrDNA stabilitytranscription

Identifiers

PMID38058218
OpenAlexW4389425762

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.