Evidence map›Paper›PMID 38058151›Full record

ArticleJournal of dental research2024

A PTHrP Gradient Drives Mandibular Condylar Chondrogenesis via Runx2.

C Tsutsumi-Arai, Y Arai, A Tran, M Salinas, Y Nakai, S Orikasa, W Ono, N Ono

Abstract read
In one paragraph

Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. A mouse model of Jansen's metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

C Tsutsumi-AraiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Y AraiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
A TranUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
M SalinasUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.
Y NakaiUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.ORCID 0000-0003-2695-6097
S OrikasaUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.ORCID 0000-0002-4226-7358
W OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.ORCID 0000-0002-0358-1897
N OnoUniversity of Texas Health Science Center at Houston School of Dentistry, Houston, TX, USA.ORCID 0000-0002-3771-8230

Funding

Craniofacial skeletal cell lineage plasticity for reconstituting stem cells and their nichesR01DE030630 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI, ONO, WANIDA · 2021 to 2025
$2.2M
Dynamics and Regulations of Bone Stem Cells in VivoR01DE026666 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, NORIAKI · 2018 to 2022
$2.1M
Pharmacological rescue of tooth eruption disordersR01DE030416 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Wanida Ono · 2023 to 2026
$1.9M
Dental Follicle: A Central Regulator of Tooth Root Formation and RegenerationR01DE029181 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ONO, WANIDA · 2021 to 2025
$1.9M
NIDCR NIH HHS R01 DE026666NIDCR NIH HHS R01 DE029181NIDCR NIH HHS R01 DE030416NIDCR NIH HHS R01 DE030630
6 · The paper itself

Abstract

The mandibular condylar cartilage (MCC) is an essential component of the temporomandibular joint, which orchestrates the vertical growth of the mandibular ramus through endochondral ossification with distinctive modes of cell differentiation. Parathyroid hormone-related protein (PTHrP) is a master regulator of chondrogenesis; in the long bone epiphyseal growth plate, PTHrP expressed by resting zone chondrocytes promotes chondrocyte proliferation in the adjacent layer. However, how PTHrP regulates chondrogenesis in the MCC remains largely unclear. In this study, we used a

Indexed as

Mandibular CondyleParathyroid Hormone-Related ProteinAnimalsCartilageCell DifferentiationChondrocytesChondrogenesisCore Binding Factor Alpha 1 SubunitMiceCore Binding Factor Alpha 1 SubunitParathyroid Hormone-Related ProteinPthlh protein, mouseRunx2 protein, mousearticular cartilagebone developmentchondrocytesmandibular condylar cartilage (MCC)periosteumtemporomandibular joint

Identifiers

PMID38058151
PMCPMC10734211

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.