ArticleDiabetology & metabolic syndrome2023
Evaluation of subclinical left ventricular systolic dysfunction in obese patients by global myocardial work.
Article in Diabetology & metabolic syndrome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 11 citations in OpenAlex.
- Analysis of myocardial work in different obesity phenotypes and its association with epicardial adipose tissue.BMC cardiovascular disorders · 2026Observational
- The Obesity Paradox in Major Adverse Cardiovascular Events After PCI for Acute Coronary Syndrome: A Narrative Review.Journal of cardiovascular development and disease · 2026Review
- Prediabetes and diabetes exacerbated cardiac systolic function in obese patients at the subclinical stage: insights from global longitudinal strain and myocardial work.Diabetology & metabolic syndrome · 2026Article
- The atherogenic index of plasma is associated with subclinical cardiac systolic dysfunction among obese patients: a cross-sectional study.Frontiers in nutrition · 2026Article
- The Contribution of Echocardiography to the Diagnosis and Prognosis Stratification of Diabetic Cardiomyopathy.Diagnostics (Basel, Switzerland) · 2025Review
- Long-term prognostic value of myocardial work analysis across obesity stages: insights from a community-based study.International journal of obesity (2005) · 2025Article
- Prognostic Significance of Left Ventricular Global Work Efficiency in Obese Patients with Acute ST-Segment Elevation Myocardial Infarction-A Pilot Study.Diagnostics (Basel, Switzerland) · 2025Article
- Subclinical Changes in Type 2 Diabetes Patients with Heart Failure Stage A and B Treated with Oral Semaglutide.Medicina (Kaunas, Lithuania) · 2025Observational
- Clinical correlates of perivascular adipose tissue in coronary artery disease and obesity.Frontiers in physiology · 2025Article
- Identification of Pre-Heart Failure in Early Stages: The Role of Six Stages of Heart Failure.Diagnostics (Basel, Switzerland) · 2024Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate subclinical LV systolic dysfunction in obese patients by global myocardial work (MW).
methodsA total of 589 obese patients and 100 normal controls were enrolled in the study. The global longitudinal strain (GLS), global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE) were generated by a noninvasive pressure-strain loop (PSL) in apical 3-, 4- and 2-chamber views acquired by two-dimensional echocardiography. All obese patients were divided into three groups: class I obesity (mild) 30-35 kg/m
resultsThe absolute value of GLS in obese patients was significantly lower than that in normal controls (P < 0.001). The values of GWI, GCW, GWE and GCW/GWW in obese patients were significantly lower than those in normal controls (P < 0.05), while GWW was significantly larger than that in normal controls (P < 0.001). Subgroup analysis and trend analysis showed that the values of GWI, GCW, GWE and GCW/GWW in severe obese patients were lower than those in moderate obese patients and lower than those in mild obese patients (P < 0.01), while GWW in severe obese patients was larger than that in moderate obese patients and larger than that in mild obese patients (P < 0.05). Female sex, BMI and SBP were independent influencing factors of impaired GWI (β = 0.15, P < 0.001) (β=-0.18, P < 0.001) (β = 0.50, P < 0.001) and GCW (β = 0.17, P < 0.001) (β=-0.19, P < 0.001) (β = 0.57, P < 0.001). ROC analysis showed that the AUC of the combined global MW was significantly higher than the AUCs of the individual indices (P < 0.05).
conclusionIn this study, we conclude that subclinical LV systolic dysfunction was detected by the novel global MW technique in obese patients. Elevated BMI in obese patients results in an increased risk of subclinical LV systolic dysfunction, although the LVEF is normal. Controlling BMI in obese patients may reduce the impairment to the LV myocardial systolic function. Global MW is a novel and reproducible technique that can be well applied in the clinical evaluation of subclinical LV systolic dysfunction.
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