ArticleBMC cardiovascular disorders2023
Association of systemic immune inflammatory index with all-cause and cause-specific mortality among individuals with type 2 diabetes.
Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Predictive value of systemic immune-inflammation index in patients with diabetes mellitus: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Pooled it
- Resolution of systemic inflammation in psoriasis following herring roe oil treatment: aFrontiers in medicine · 2026Article
- Associations of Inflammatory Prognosis Index With All-Cause and Cardiovascular Mortality Among Individuals With Diabetes and Prediabetes: A Retrospective Cohort Study.Mediators of inflammation · 2026Article
- Relationship Between Comprehensive Inflammatory Indicators and Gout Risk: A Cross-sectional Study Based on NHANES 2015-2018.Endocrine, metabolic & immune disorders drug targets · 2026Article
- Inflammation Beyond the Prostate: The Role of Systemic Inflammatory Disorders in Prostate Carcinogenesis.Cureus · 2025Review
- The mediating role of inflammatory factors in the association between dietary index for gut microbiota and hypertension.Scientific reports · 2025Article
- Prognostic value of systemic immune-Inflammatory index in patients with diabetes mellitus and acute coronary syndrome after percutaneous coronary intervention: a prospective cohort study.BMC cardiovascular disorders · 2025Article
- A scoring model integrating CXCL9, GDF15, FGF21, and NfL, predicts long-term mortality in type 2 diabetes: a retrospective study.Cardiovascular diabetology · 2025Article
- The prognostic value of the systemic immunity-inflammation index for cardiovascular and all-cause mortality in cardiovascular disease patients with diabetes or prediabetes.Journal of diabetes investigation · 2025Article
- The U-shaped association of fasting plasma glucose to HbA1c ratio with mortality in diabetic and prediabetic populations: the mediating role of systemic immune-inflammation index.Frontiers in endocrinology · 2025Article
- Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older.Frontiers in aging · 2025Article
- Neutrophil-lymphocyte ratio and systemic immune-inflammation index as predictors of cardiovascular risk and mortality in prediabetes and diabetes: a population-based study.Inflammopharmacology · 2024Article
- Article
- Association of systemic immune-inflammation index with all-cause and cardio-cerebrovascular mortality in individuals with diabetic kidney disease: evidence from NHANES 1999-2018.Frontiers in endocrinology · 2024Article
- Editorial: Inflammation and chronic disease.Frontiers in medicine · 2024Article
- The single and mixed impacts of cadmium, cobalt, lead, and PAHs on systemic immunity inflammation index in male and female.Frontiers in public health · 2024Article
- Nonlinear association of the systemic immune-inflammatory index with mortality in diabetic patients.Frontiers in endocrinology · 2024Article
- Association between the systemic immune-inflammation index and the outcome of liver fibrosis in patients with chronic hepatitis C.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe evidence regarding the association between the systemic immune inflammatory index (SII) and mortality among individuals with diabetes is limited. This study aims to evaluate the associations between SII and all-cause and cause-specific mortality among individuals with diabetes.
methodsThe study included 8,668 participants with diabetes from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 with follow-up until 31 December 2019. The calculation of SII in this study was performed using the following formula: the neutrophil-to-lymphocyte ratio multiplied by the platelet count (10^9 cells/µL).
resultsThe study documented 2,463 deaths over 68,542 person-years, including 853 deaths from CVD and 424 from cancer. An increase in SII was significantly associated with higher all-cause and CVD mortality risk after multivariate adjustment. For each standard deviation increment in natural log transformed SII (lnSII), all-cause mortality increased by 17%, and CVD mortality increased by 34% (both P < 0.001). Additionally, the association between SII and all-cause mortality was U-shaped, with the inflection point at 6.02. The association between SII and CVD mortality was non-linear and J-shaped, where the risk increased significantly when lnSII exceeded 6.22. Furthermore, the association between SII and CVD mortality was attenuated in female and hyperlipidemia patients.
conclusionIn this study, we observed a significant positive association between the SII and both all-cause and CVD mortality in patients with diabetes. Additionally, it was discovered that this association exhibited a non-linear pattern. These findings suggest that maintaining SII within an optimal range may play a critical role in mitigating the risk of mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.