Evidence map›Paper›PMID 38057668›Full record

ArticleNature2024

Dictionary of immune responses to cytokines at single-cell resolution.

Ang Cui, Teddy Huang, Shuqiang Li, Aileen Ma, Jorge L Pérez, Chris Sander, Derin B Keskin, Catherine J Wu, Ernest Fraenkel, Nir Hacohen

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 247 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
247citing papers in PubMed, 1 pooled it
46.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

247 citing papers in PubMed, 1 synthesis or guideline pooled it, 304 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Dendritic cell PD-L2 restrains intratumoral CD8bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
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  16. Review
  17. Article
  18. Article
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  20. Article

187 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ang CuiHarvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. ang_cui@g.harvard.edu.ORCID 0000-0002-1087-8568
Teddy HuangTranslational Immunogenomics Lab, Dana-Farber Cancer Institute, Boston, MA, USA.
Shuqiang LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9106-6141
Aileen MaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-8665-8772
Jorge L PérezBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-3119-1359
Chris SanderBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6059-6270
Derin B KeskinBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Catherine J WuBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3348-5054
Ernest FraenkelBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9249-8181
Nir HacohenBroad Institute of MIT and Harvard, Cambridge, MA, USA. nhacohen@mgh.harvard.edu.ORCID 0000-0002-2349-2656
Broad Institute · USDana-Farber Cancer Institute · US

Funding

Center for Cell CircuitsRM1HG006193 · NHGRI · BROAD INSTITUTE, INC. · PI BLAINEY, PAUL CLARK, HACOHEN, NIR · 2016 to 2020
$14.9M
Single Cell and ImmunogenomicsP01CA229092 · NCI · DANA-FARBER CANCER INST · PI SOIFFER, ROBERT JON · 2019 to 2023
$13.8M
Personal tumor neoantigens for immunity against chronic lymphocytic leukemiaR01CA155010 · NCI · DANA-FARBER CANCER INST · PI Catherine Ju-Ying Wu · 2011 to 2026
$9.6M
Single cell investigation of co-evolution in cancer cells and host cell immune microenvironmentR50CA251956 · NCI · DANA-FARBER CANCER INST · PI Shuqiang Li · 2020 to 2026
$1.4M
NCI NIH HHS P01 CA229092NCI NIH HHS R01 CA155010NCI NIH HHS R50 CA251956NHGRI NIH HHS RM1 HG006193
6 · The paper itself

Abstract

Cytokines mediate cell-cell communication in the immune system and represent important therapeutic targets

Indexed as

CytokinesImmunitySingle-Cell AnalysisAnimalsCell CommunicationGene Expression ProfilingGene Expression RegulationImmune Checkpoint InhibitorsInterleukin-18Interleukin-1betaKiller Cells, NaturalLymph NodesMiceNeoplasmsSignal TransductionSoftwareCytokinesImmune Checkpoint InhibitorsInterleukin-18Interleukin-1beta

Identifiers

PMID38057668
PMCPMC10781646
OpenAlexW4389390583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.