ArticleNature2024
A human embryonic limb cell atlas resolved in space and time.
Open access · hybridAbstract readComparative Study
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
17.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
81 citing papers in PubMed, 112 citations in OpenAlex.
- High-Risk Rhabdomyosarcomas Feature a Convergent Cell State.Cancer research · 2026Article
- A systematic assessment of single-cell language model configurations.NAR genomics and bioinformatics · 2026Article
- DEAPLOG: Differential Expression Analysis and Pseudo-Temporal Locating and Ordering of Genes in Single-Cell Transcriptomic Data.Interdisciplinary sciences, computational life sciences · 2026Article
- A Microenvironment-Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- STAID: A Self-Refining Deep Learning Framework for Spatial Cell-Type Deconvolution with Biologically Informed Modeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Conserved anterior/posterior tissue asymmetry encodes proximal/distal positional information during axolotl limb regeneration.Cell reports · 2026Article
- Trimodal, uncertainty-guided whole-slide framework for genome-scale spatial expression and image-only virtual perturbation in cancer cohorts.Genome medicine · 2026Article
- Segmental specification of the human female fetal reproductive tract revealed by spatiotemporal dynamics.Nature cell biology · 2026Article
- Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens.Neuron · 2026Article
- Dissecting the genetic architecture of knee alignment reveals its contribution to osteoarthritis risk.medRxiv : the preprint server for health sciences · 2026Article
- Excessive postnatal smooth muscle differentiation in a lung-specific model of TBX4-related pulmonary hypertension.JCI insight · 2026Article
- Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation.Cell death and differentiation · 2026Article
- Modular genetic architecture underlies human hand and foot evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- METTL5 deficiency impairs osteogenesis through OSER1-dependent antioxidant regulation.JCI insight · 2026Article
- Type E endothelial cells orchestrate embryonic skeletogenesis via chondrogenic priming of skeletal progenitors.Journal of orthopaedic translation · 2026Article
- [Advances in the role of miR-378a in skeletal muscle development and diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Review
- Aging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers.Journal of advanced research · 2026Review
- Spatial single cell transcriptomic analysis informs tumor developmental hierarchy of DICER1 syndrome related sarcoma.Nature communications · 2026Article
- Stage- and cluster-specific regulation of chondrogenic gene programs by Sox9 in mouse embryonic limb buds.iScience · 2026Article
21 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 10 institutions in 5 countries.
Bao Zhang *The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0003-1563-7103
Peng He *European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0002-2457-3554
John E G Lawrence *Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Shuaiyu Wang *The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Elizabeth TuckWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Brian A WilliamsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-3253-611X
Kenny RobertsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-6155-0821
Vitalii KleshchevnikovWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Lira MamanovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Liam BoltWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-7293-0774
Krzysztof PolanskiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0002-2586-9576
Tong LiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0002-8240-4476
Rasa ElmentaiteWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-7366-5466
Eirini S FasouliWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Martin PreteWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0002-5946-821X
Xiaoling HeJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Nadav YayonEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.
Yixi FuThe Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Hao YangThe Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Chen LiangThe Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Hui ZhangInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.ORCID 0000-0003-3620-610X
Raphael BlainSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.ORCID 0000-0002-8552-0229
Alain ChedotalSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.ORCID 0000-0001-7577-3794
David R FitzPatrickMRC Human Genetics Unit, IGC, University of Edinburgh, WGH, Edinburgh, UK.
Helen FirthWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Andrew DeanDepartment of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation, Cambridge, UK.
Omer Ali BayraktarWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-6055-277X
John C MarioniEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, UK.ORCID 0000-0001-9092-0852
Roger A BarkerJohn van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Mekayla A StorerWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Barbara J WoldDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID 0000-0003-3235-8130
Hongbo ZhangThe Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. zhanghongbo@mail.sysu.edu.cn.ORCID 0000-0002-4081-5752
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. st9@sanger.ac.uk.ORCID 0000-0002-6294-6366
Wellcome Sanger Institute · GBSun Yat-sen University · CNEuropean Bioinformatics Institute · GBWellcome/MRC Cambridge Stem Cell Institute · GBCalifornia Institute of Technology · USCambridge University Hospitals NHS Foundation Trust · GBCentre National de la Recherche Scientifique · FRInstitute of Genetics and Cancer · GBUniversité Claude Bernard Lyon 1 · FRUniversity of Cambridge · GB
Funding
Medical Research Council MC_PC_17230Medical Research Council MC_UU_00007/3Medical Research Council MR/S036237/1Wellcome Trust 206194Wellcome Trust 211276Wellcome Trust 222902
Abstract
Human limbs emerge during the fourth post-conception week as mesenchymal buds, which develop into fully formed limbs over the subsequent months
Indexed as
ExtremitiesSingle-Cell AnalysisTranscriptomeAnimalsAtlases as TopicBasic Helix-Loop-Helix ProteinsBrachydactylyCell DifferentiationFemaleFetusGene Expression Regulation, DevelopmentalHumansLegLimb BudsMesodermMiceBasic Helix-Loop-Helix ProteinsMSC protein, humanRepressor Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.