ArticleNature2023
Organ aging signatures in the plasma proteome track health and disease.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06613542 (Effect Of Daily Taurine Supplementation For 6 Months On Biological Age and Metabolic Biomarkers As Well As Physical Fitness In 55-75-year-old Women And Men), which is not on this map. Cited by 415 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
415citing papers in PubMed, 1 pooled it
87.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect Of Daily Taurine Supplementation For 6 Months On Biological Age and Metabolic Biomarkers As Well As Physical Fitness In 55-75-year-old Women And Men: A Randomized Controlled Intervention Study
Who cites it
415 citing papers in PubMed, 1 synthesis or guideline pooled it, 501 citations in OpenAlex.
- [Liquid biopsy proteomics in ophthalmology : A clinical and scientific perspective].Die Ophthalmologie · 2026Pooled it
- Cardiovascular Responses to Natural and Auditory Evoked Slow Waves Predict Post-Sleep Cardiac Function.Journal of sleep research · 2026Trial
- Neurobiological markers across joint profiles of subjective cognitive decline and objective cognitive function in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Cognitive and Brain Reserve as Modifiers of Early Alzheimer Disease-Related Cognitive Vulnerability.Neurology · 2026Trial
- Trial
- Gero-Immunology: The critical role of aging when defining immune phenotypes.Current opinion in biomedical engineering · 2026Article
- Novel cell markers with altered expression in brain aging and Alzheimer's disease: A review.IBRO neuroscience reports · 2026Article
- Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging.The Journal of clinical investigation · 2026Review
- Interpreting ocular age estimates: source, output, evidence, and clinical meaning.Biogerontology · 2026Review
- A roadmap towards clinical use of molecular biomarkers in acute ischaemic stroke.Nature reviews. Neurology · 2026Review
- [The Nephrogeriatrics Research Network-achieving more through interdisciplinary approaches].Innere Medizin (Heidelberg, Germany) · 2026Review
- Birthweight and Breastfeeding Shape Patterns of Biological Aging Across Adult Organs.Aging cell · 2026Article
- Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All-Cause Mortality.Aging cell · 2026Article
- Vascular aging as a driver of organ dysfunction and systemic aging.Nature cardiovascular research · 2026Review
- A Deep-Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes.Aging cell · 2026Article
- A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions.Ageing research reviews · 2026Review
- Multi-omic analysis of canine aging uncovers conserved aging pathways.GeroScience · 2026Article
- Organ-Specific Proteomic Aging Clocks Reveal Complexities Underlying the Healthy Drinking Paradox.Aging cell · 2026Review
- Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories.Biogerontology · 2026Article
- Sex-specific biological aging clocks across organs and omics.Nature medicine · 2026Article
355 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
36 authors at 6 institutions in 1 country.
Hamilton Se-Hwee Oh *Graduate Program in Stem Cell and Regenerative Medicine, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8192-7593
Jarod Rutledge *The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7790-2801
Daniel NachunDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Róbert PálovicsThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Olamide AbioseWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Patricia Moran-LosadaThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Divya ChannappaThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Deniz Yagmur UreyThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Kate KimThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Yun Ju SungDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0002-8021-4070
Lihua WangDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.
Jigyasha TimsinaDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.
Dan WesternDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.ORCID 0000-0003-3725-9553
Menghan LiuDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.ORCID 0009-0008-9902-5983
Pat KohlfeldDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.ORCID 0009-0004-9206-8244
John BuddeDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.
Edward N WilsonWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0640-5247
Yann GuenDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6649-8364
Taylor M MaurerDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Michael HaneyThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA.
Andrew C YangDepartments of Neurology and Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6756-4746
Zihuai HeDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Michael D GreiciusDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Katrin I AndreassonWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8391-4155
Sanish SathyanDepartments of Medicine and Genetics, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.
Erica F WeissDepartment of Neurology, Montefiore Medical Center, New York, NY, USA.ORCID 0000-0002-0726-7547
Sofiya MilmanDepartments of Medicine and Genetics, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.ORCID 0000-0001-9247-0082
Nir BarzilaiDepartments of Medicine and Genetics, Institute for Aging Research, Albert Einstein College of Medicine, New York, NY, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University in St Louis, St Louis, MO, USA.
Anthony D WagnerWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0624-4543
Elizabeth MorminoDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Benoit LehallierDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Victor W HendersonWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1198-9240
Frank M LongoWu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA.
Stephen B MontgomeryDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5200-3903
Tony Wyss-CorayThe Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, CA, USA. twc@stanford.edu.ORCID 0000-0001-5893-0831
Neurosciences Institute · USStanford University · USWashington University in St. Louis · USAlbert Einstein College of Medicine · USGladstone Institutes · USMontefiore Medical Center · US
Funding
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MStanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0MTranslational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MThe effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MEinstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HUFFMAN, DEREK MAJOR · 2010 to 2024
$10.8MWorking Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2015 to 2019
$7.9MResilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2MRole of exceptional longevity genotypes in protection against frailty in agingR01AG044829 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sofiya Milman, JOE VERGHESE · 2014 to 2026
$5.4MStanford Training Program in Aging ResearchT32AG047126 · NIA · STANFORD UNIVERSITY · PI VYJEYANTHI S PERIYAKOIL, TONY WYSS-CORAY · 2014 to 2026
$4.3MSomatotropic Signaling and Resilience to Aging and Alzheimer's DiseaseR01AG061155 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MILMAN, SOFIYA · 2019 to 2023
$4.3MUSING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0MMapping Molecular and Phenotypic Interactions in Alzheimers DiseaseR01AG066490 · NIA · STANFORD UNIVERSITY · PI MONTGOMERY, STEPHEN · 2020 to 2024
$3.6MNIAID NIH HHS P01 AI153559NIA NIH HHS P01 AG003991NIA NIH HHS P30 AG038072NIA NIH HHS P30 AG066515NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG044829NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG061155NIA NIH HHS R01 AG066206NIA NIH HHS R01 AG066490NIA NIH HHS R01 AG072255NIA NIH HHS R56 AG044829NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS RF1 AG074007NIA NIH HHS T32 AG047126NIA NIH HHS U01 AG058922NIDDK NIH HHS P30 DK020541
Abstract
Animal studies show aging varies between individuals as well as between organs within an individual
Indexed as
AgingBiomarkersDiseaseHealthOrgan SpecificityProteomeProteomicsAdultAlzheimer DiseaseBrainCognitive DysfunctionCohort StudiesDisease ProgressionExtracellular MatrixHeartHeart FailureBiomarkersMAPT protein, humanProteometau Proteins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06613542ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.