Evidence map›Paper›PMID 38057332›Full record

ArticleScientific reports2023

Abcc6 deficiency prevents rhabdomyolysis-induced acute kidney injury.

Audrey Casemayou, Julie Belliere, Emmanuel Letavernier, Eloïse Colliou, Hélène El Hachem, Jeremy Zarowski, Dominique Bazin, Clément Kounde, Alexis Piedrafita, Guylène Feuillet and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Audrey CasemayouDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France.
Julie BelliereDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France.
Emmanuel LetavernierNational Institute of Health and Medical Research, (INSERM) UMR S 1155, Tenon Hospital, 75020, Paris, France.
Eloïse ColliouDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France.
Hélène El HachemDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France.
Jeremy ZarowskiDepartment of Physiology, Tenon Hospital, Assistance Publique - Hôpitaux de Paris, 75020, Paris, France.
Dominique BazinLaboratory of Chemistry and Physics, CNRS UMR 8000, University Paris XI, 91405, Orsay, France.
Clément KoundeDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France.
Alexis PiedrafitaDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France.
Guylène FeuilletNational Institute of Health and Medical Research (INSERM), Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR 1297, Rangueil Hospital, 31000, Toulouse, France.
Joost P SchanstraNational Institute of Health and Medical Research (INSERM), Institute of Metabolic and Cardiovascular Diseases (I2MC), UMR 1297, Rangueil Hospital, 31000, Toulouse, France.
Stanislas FaguerDepartment of Nephrology and Organ Transplantation, Reference Centre for Rare Kidney Diseases (SORARE), French Intensive Care Renal Network (FIRN), University Hospital of Toulouse, 1, Avenue du Pr. Jean Poulhes, 31059, Toulouse Cedex, France. stanislas.faguer@inserm.fr.
Inserm · FRCentre National de la Recherche Scientifique · FRSorbonne Université · FR

Funding

ERA PerMed-JTC 2018 ANR-18-PERM-0003Fondation pour la Recherche Médicale DEQ20170336759Université Toulouse III - Paul Sabatier Ecole doctorale BSB
6 · The paper itself

Abstract

Rhabdomyolysis is a risk factor for acute kidney injury, transition towards chronic kidney disease, and death. The role of calcium phosphate deposits in the mechanisms of rhabdomyolysis-induced acute kidney injury (RAKI) is still unclear. Better insight of the role calcium in RAKI could lead to new therapeutic avenues. Here, we show in a mice model of RAKI that calcium phosphate deposits were frequent in the kidney (hydroxyapatite) and partly correlated with the severity of the kidney injury. However, the intensity of deposits was highly heterogeneous between mice. Treatment with sodium chloride, sodium bicarbonate or inorganic pyrophosphate (PPi; an inhibitor of the calcium phosphate crystallization), or combinations thereof, did not improve kidney outcomes and hydroxyapatite deposition during RAKI. Unexpectedly, Abcc6 knockout mice (ko), characterized by PPi deficiency, developed less severe RAKI despite similar rhabdomyolysis severity, and had similar hydroxyapatite deposition suggesting alternative mechanisms. This improved kidney outcome at day 2 translated to a trend in improved glomerular filtration rate at month 2 in Abcc6

Indexed as

Acute Kidney InjuryRhabdomyolysisAnimalsATP-Binding Cassette, Sub-Family C ProteinsCalcium PhosphatesFibrosisHydroxyapatitesKidneyMiceMice, KnockoutSodium BicarbonateSodium ChlorideAbcc6 protein, mouseATP-Binding Cassette, Sub-Family C ProteinsCalcium PhosphatesHydroxyapatitesSodium BicarbonateSodium Chloride

Identifiers

PMID38057332
PMCPMC10700332
OpenAlexW4389399221

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.