ArticleNature communications2023
Docking for EP4R antagonists active against inflammatory pain.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- 15-PGDH inhibition in osteoarthritis: PGEBone research · 2026Review
- Structure based discovery of antipsychotic-like TAAR1 agonists.Nature communications · 2026Article
- Docking-based virtual screening: Past, present, and future.Biophysical journal · 2026Review
- Chemical Distance-Based Acceleration of Large Library Docking with ChemSTEP.ACS central science · 2026Article
- Prioritizing neuroactive ligands using motif-guided virtual discovery and zebrafish profiling.npj drug discovery · 2026Article
- Preoperative ketorolac is associated with increased nonunion repair following femoral intramedullary nailing: a retrospective cohort study.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- The Selectivity Implications of Docking Libraries with Greater and Lesser Similarities to Bio-like Molecules.Journal of medicinal chemistry · 2026Article
- Open-Source Molecular Docking and AI-Augmented Structure-Based Drug Design: Current Workflows, Challenges, and Opportunities.International journal of molecular sciences · 2026Review
- Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators.bioRxiv : the preprint server for biology · 2026Article
- The selectivity implications of docking libraries with greater and lesser similarities to bio-like molecules.bioRxiv : the preprint server for biology · 2026Article
- Prioritizing Neuroactive Ligands Using Motif-Guided Virtual Discovery and Zebrafish Profiling.bioRxiv : the preprint server for biology · 2026Article
- Study on the analgesic and anti-inflammatory mechanisms of Jingu Zhitong gel in the treatment of knee osteoarthritis through the IL-17, NGF-TrkA, and COX-2/PGE2 pathways.Frontiers in pharmacology · 2026Article
- Electroacupuncture alleviates inflammatory pain by modulating the CXCL1/CXCR2 signaling axis in the spinal cord dorsal horn of rats.Frontiers in molecular neuroscience · 2026Article
- The neural circuits and signalling pathways of opioid use disorder.Nature reviews. Neuroscience · 2025Review
- Targeting prostaglandin ENature communications · 2025Article
- The impact of library size and scale of testing on virtual screening.Nature chemical biology · 2025Article
- Biased agonism of G protein-coupled receptors as a novel strategy for osteoarthritis therapy.Bone research · 2025Review
- A Database for Large-Scale Docking and Experimental Results.Journal of chemical information and modeling · 2025Article
- Cartilage-targeting peptide-modified cerium oxide nanoparticles alleviate oxidative stress and cartilage damage in osteoarthritis.Journal of nanobiotechnology · 2024Article
- Docking‑based virtual screening of BRD4 (BD1) inhibitors: assessment of docking methods, scoring functions and in silico molecular properties.BMC chemistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 4 institutions in 3 countries.
Stefan Gahbauer *Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-3115-9757
Chelsea DeLeon *Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.
Joao M Braz *Department of Anatomy, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-5792-1017
Veronica CraikDepartment of Anatomy, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0001-5463-1199
Hye Jin KangDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.ORCID 0000-0001-9067-9050
Xiaobo WanDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.
Xi-Ping HuangDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.
Christian B BillesbølleDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0001-8084-1552
Yongfeng LiuDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.ORCID 0000-0002-8649-7892
Tao CheDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.ORCID 0000-0002-1620-3027
Ishan DeshpandeDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.
Madison JewellDepartment of Anatomy, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0009-0004-8337-1583
Elissa A FinkDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0001-5531-1971
Ivan S KondratovEnamine Ltd., Kyiv, Ukraine.
Yurii S MorozChemspace LLC, Kyiv, Ukraine.ORCID 0000-0001-6073-002X
John J IrwinDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-1195-6417
Allan I BasbaumDepartment of Anatomy, University of California San Francisco, San Francisco, CA, 94158, USA. allan.basbaum@ucsf.edu.ORCID 0000-0002-1710-6333
Bryan L RothDepartment of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA. bryan_roth@med.unc.edu.ORCID 0000-0002-0561-6520
Brian K ShoichetDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, 94158, USA. bshoichet@gmail.com.ORCID 0000-0002-6098-7367
University of California, San Francisco · USUniversity of North Carolina at Chapel Hill · USNational Academy of Sciences of Ukraine · UATaras Shevchenko National University of Kyiv · UA
Funding
Development and Testing of New Computational Methods for Ligand Discovery and MechanismR35GM122481 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Brian K Shoichet · 2017 to 2026
$8.5MFrom the spinal cord to the brain: Neurology of the pain and itch neuronsR35NS097306 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BASBAUM, ALLAN I. · 2017 to 2024
$7.2MMolecular Biophysics Training GrantT32GM149436 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aashish Manglik · 2023 to 2026
$1.6MUltra-large library docking for ligand discoveryR01GM133836 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI IRWIN, JOHN J. · 2019 to 2022
$1.6MNIGMS NIH HHS R01 GM133836NIGMS NIH HHS R35 GM122481NIGMS NIH HHS T32 GM149436NINDS NIH HHS R35 NS097306
Abstract
The lipid prostaglandin E
Indexed as
DinoprostoneReceptors, ProstaglandinAnimalsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalHumansMicePainPhagocytosisAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalDinoprostoneReceptors, Prostaglandin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.