Evidence map›Paper›PMID 38057307›Full record

ArticleNature communications2023

Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa.

Weiyin Zhou, Anja Fischer, Martin D Ogwang, Wen Luo, Patrick Kerchan, Steven J Reynolds, Constance N Tenge, Pamela A Were, Robert T Kuremu, Walter N Wekesa and 37 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 17 institutions in 8 countries.

Weiyin ZhouDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Anja FischerInstitute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.ORCID 0000-0002-7145-2544
Martin D OgwangEMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
Wen LuoDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Patrick KerchanEMBLEM Study, Kuluva Hospital, Arua, Uganda.
Steven J ReynoldsDivision of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Constance N TengeEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
Pamela A WereEMBLEM Study, Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.
Robert T KuremuEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
Walter N WekesaEMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
Nestory MasaluEMBLEM Study, Bugando Medical Center, Mwanza, Tanzania.
Esther KawiraEMBLEM Study, Shirati Health, Education, and Development Foundation, Shirati, Tanzania.
Tobias KinyeraEMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
Isaac OtimEMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
Ismail D LegasonEMBLEM Study, Kuluva Hospital, Arua, Uganda.ORCID 0000-0002-6118-542X
Hadijah NabalendeEMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
Leona W AyersDepartment of Pathology, The Ohio State University, Columbus, OH, USA.
Kishor BhatiaDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
James J GoedertDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Mateus H GouveiaCenter for Research on Genomics & Global Health, NHGRI, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-6711-5265
Nathan ColeDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Belynda HicksDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.ORCID 0000-0001-8014-4888
Kristine JonesDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Michael HummelCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany.
Mathias SchlesnerBiomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany.ORCID 0000-0002-5896-4086
George ChagalukaDepartments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
Nora MutalimaEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
Eric BorgsteinDepartments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
George N LiombaDepartments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
Steve KamizaDepartments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
Nyengo MkandawireDepartments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
Collins MitamboResearch Department, Ministry of Health, P.O. Box 30377, Lilongwe 3, Malawi.
Elizabeth M MolyneuxDepartments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
Robert NewtonEpidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.ORCID 0000-0001-6715-9153
Selina GlaserInstitute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
Helene KretzmerDepartment of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Michelle ManningDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
Ann W HsingStanford Cancer Institute, Stanford University, Stanford, Palo Alto, CA, USA.
Yao TetteyDepartment of Pathology, University of Ghana Medical School, College of Health Sciences, P.O. Box KB 52, Korle-Bu, Accra, Ghana.
Andrew A AdjeiDepartment of Pathology, University of Ghana Medical School, College of Health Sciences, P.O. Box KB 52, Korle-Bu, Accra, Ghana.
Stephen J ChanockDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.ORCID 0000-0002-2324-3393
Reiner SiebertInstitute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
Meredith YeagerDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.ORCID 0000-0003-3871-2225
Ludmila Prokunina-OlssonDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.ORCID 0000-0002-9622-2091
Mitchell J MachielaDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.ORCID 0000-0001-6538-9705
Sam M MbulaiteyeDivision of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA. mbulaits@mail.nih.gov.ORCID 0000-0002-8273-9831
National Institutes of Health · USUniversity of Malawi · MWSt. Mary's Hospital Lacor · UGMoi University · KEUniversität Ulm · DEKuluva Hospital · UGUniversity of Ghana · GHAMPATH · KEBugando Medical Centre · TZHumboldt-Universität zu Berlin · DEMax Planck Institute for Molecular Genetics · DEMinistry of Health · MWStanford University · USThe Ohio State University · USUniversity of Augsburg · DEUniversity of Oxford · GBUniversity of York · GB

Funding

Medical Research Council MC_UU_00033/1NCI NIH HHS HHSN261201100007INCI NIH HHS HHSN261201100063CNHLBI NIH HHS HHSN261201100007C
6 · The paper itself

Abstract

In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10

Indexed as

Burkitt LymphomaChildChromosome AberrationsGhanaHumansImmunoglobulinsLeukocytesMaleTranslocation, GeneticImmunoglobulins

Identifiers

PMID38057307
PMCPMC10700489
OpenAlexW4389379265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.