ArticleBrain stimulation
Multi-scale model of axonal and dendritic polarization by transcranial direct current stimulation in realistic head geometry.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Linking electric field directionality to treatment outcome in OCD: Insights from patient-specific tDCS modeling.Translational psychiatry · 2026Trial
- Independent effects of transcranial direct current stimulation and social influence on pain.Pain · 2025Trial
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017-2025: An update) - endorsed by the European Society for Brain Stimulation (ESBS) and by the International Federation for Clinical Neurophysiology (IFCN).Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
- Efficacy and mechanisms underlying MRI-guided HD-tDCS combined with aerobic exercise to ameliorate cognitive impairment associated with schizophrenia.Frontiers in psychiatry · 2026Article
- Predicting neural responses to intra- and extra-cranial electric brain stimulation by means of the reciprocity theorem.PLoS computational biology · 2025Article
- Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies.Journal of neural engineering · 2025Review
- Computational Optimization of Spinal Cord Stimulation for Dorsal Horn Interneuron Polarization.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Article
- Effects of dendritic CaJournal of computational neuroscience · 2025Article
- Open-End Control of Neurite Outgrowth Lengths with Steep Bending Confinement Microchannel Patterns for Miswiring-Free Neuronal Network Formation.Micromachines · 2024Article
- Multi-scale modeling to investigate the effects of transcranial magnetic stimulation on morphologically-realistic neuron with depression.Cognitive neurodynamics · 2024Article
- Head and shoulders-The impact of an extended head model on the simulation and optimization of transcranial electric stimulation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Subthreshold electric fields bidirectionally modulate neurotransmitter release through axon polarization.Brain stimulationArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundTranscranial direct current stimulation (tDCS) is a non-invasive brain stimulation modality that can alter cortical excitability. However, it remains unclear how the subcellular elements of different neuron types are polarized by specific electric field (E-field) distributions.
objectiveTo quantify neuronal polarization generated by tDCS in a multi-scale computational model.
methodsWe embedded layer-specific, morphologically-realistic cortical neuron models in a finite element model of the E-field in a human head and simulated steady-state polarization generated by conventional primary-motor-cortex-supraorbital (M1-SO) and 4 × 1 high-definition (HD) tDCS. We quantified somatic, axonal, and dendritic polarization of excitatory pyramidal cells in layers 2/3, 5, and 6, as well as inhibitory interneurons in layers 1 and 4 of the hand knob.
resultsAxonal and dendritic terminals were polarized more than the soma in all neurons, with peak axonal and dendritic polarization of 0.92 mV and 0.21 mV, respectively, compared to peak somatic polarization of 0.07 mV for 1.8 mA M1-SO stimulation. Both montages generated regions of depolarization and hyperpolarization beneath the M1 anode; M1-SO produced slightly stronger, more diffuse polarization peaking in the central sulcus, while 4 × 1 HD produced higher peak polarization in the gyral crown. The E-field component normal to the cortical surface correlated strongly with pyramidal neuron somatic polarization (R
conclusionsPolarization of pre- and postsynaptic compartments of excitatory and inhibitory cortical neurons may play a significant role in tDCS neuromodulation. These effects cannot be predicted from the E-field distribution alone but rather require calculation of the neuronal response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.