Evidence map›Paper›PMID 38056248›Full record

ArticleCytokine2024

Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis.

Malabendu Jana, Susanta Mondal, Arundhati Jana, Kalipada Pahan

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Cytokine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Malabendu JanaDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Susanta MondalDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Arundhati JanaDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Kalipada PahanDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, IL, USA. Electronic address: Kalipada_Pahan@rush.edu.
Rush University Medical Center · US

Funding

Muscle building supplement HMB for remyelinationR01AT010980 · NCCIH · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2020 to 2024
$2.7M
Characterizing novel hippocampal drugs for Alzheimer's diseaseR01AG050431 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI PAHAN, KALIPADA · 2016 to 2020
$2.1M
Cinnamon and traumatic brain injuryI01BX005002 · VA · JESSE BROWN VA MEDICAL CENTER · PI PAHAN, KALIPADA · 2020 to 2024
–
Remyelination by intranasal TIDM peptideI01BX005613 · VA · JESSE BROWN VA MEDICAL CENTER · PI PAHAN, KALIPADA · 2023 to 2025
–
BLR&D Research Career Scientist ApplicationIK6BX004982 · VA · JESSE BROWN VA MEDICAL CENTER · PI KALIPADA PAHAN · 2020 to 2026
–
BLRD VA I01 BX005002BLRD VA I01 BX005613BLRD VA IK6 BX004982NCCIH NIH HHS R01 AT010980NIA NIH HHS R01 AG050431
6 · The paper itself

Abstract

The level of IL-2 increases markedly in serum and central nervous system (CNS) of patients with multiple sclerosis (MS) and animals with experimental allergic encephalomyelitis (EAE). However, mechanisms by which IL-2 is induced under autoimmune demyelinating conditions are poorly understood. The present study underlines the importance of IL-12p40 homodimer (p40

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisAnimalsHumansInterleukin-12Interleukin-2Interleukin-23MacrophagesMiceMicrogliaRNA, MessengerInterleukin-12Interleukin-2Interleukin-23RNA, MessengerIL-12IL-12p40(2)IL-12RIL-2IL-23MicrogliaNeuroinflammation

Identifiers

PMID38056248
PMCPMC10872483
OpenAlexW4389357071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.