Evidence map›Paper›PMID 38056245›Full record

ArticleCancer epidemiology2024

Geographic and temporal trends in pediatric and young adult brain tumors in Kentucky, 1995-2019.

W J Christian, C J Walker, J McDowell, B Huang, T C Tucker, J Villano, E B Durbin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

W J ChristianDept. of Epidemiology & Environmental Health, College of Public Health, University of Kentucky, USA; Markey Cancer Center, University of Kentucky, USA. Electronic address: jay.christian@uky.edu.
C J WalkerDept. of Behavioral Science, College of Medicine, University of Kentucky, USA.
J McDowellDept. of Epidemiology & Environmental Health, College of Public Health, University of Kentucky, USA; Kentucky Cancer Registry, USA.
B HuangKentucky Cancer Registry, USA; Markey Cancer Center, University of Kentucky, USA; Div. of Cancer Biostatistics, Dept. of Internal Medicine, College of Medicine, University of Kentucky, USA.
T C TuckerDept. of Epidemiology & Environmental Health, College of Public Health, University of Kentucky, USA; Kentucky Cancer Registry, USA; Markey Cancer Center, University of Kentucky, USA.
J VillanoMarkey Cancer Center, University of Kentucky, USA; Dept. of Internal Medicine, College of Medicine, University of Kentucky, USA.
E B DurbinDiv. of Biomedical Informatics, Dept. of Internal Medicine, College of Medicine, University of Kentucky, USA; Kentucky Cancer Registry, USA; Markey Cancer Center, University of Kentucky, USA.
Markey Cancer Center · USUniversity of Kentucky · US

Funding

University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3M
NCI NIH HHS P30 CA177558
6 · The paper itself

Abstract

introductionPediatric and young adult brain tumors (PYBT) account for a large share of cancer-related morbidity and mortality among children in the United States, but their etiology is not well understood. Previous research suggests the Appalachian region of Kentucky has high rates of PYBT. This study explored PYBT incidence over 25 years in Kentucky to identify geographic and temporal trends and generate hypotheses for future research.

methodsThe Kentucky Cancer Registry contributed data on all PYBT diagnosed among those aged 0-29 during years 1995-2019. Age- and sex-adjusted spatio-temporal scan statistics-one for each type of PYBT, and one for all types-comprised the primary analysis. These results were mapped along with environmental and occupational data.

resultsFindings indicated that north-central Kentucky and the Appalachian region experienced higher rates of some PYBT. High rates of astrocytomas were clustered in a north-south strip of central Kentucky toward the end of the study period, while high rates of other specified types of intracranial and intraspinal neoplasms were significantly clustered in eastern Kentucky. The area where these clusters overlapped, in north-central Kentucky, had significantly higher rates of PYBT generally. DISCUSSION: This study demonstrates north-central Kentucky and the Appalachian region experienced higher PYBT risk than the rest of the state. These regions are home to some of Kentucky's signature industries, which should be examined in further research. Future population-based and individual-level studies of genetic factors are needed to explore how the occupations of parents, as well as prenatal and childhood exposures to pesticides and air pollutants, impact PYBT incidence.

Indexed as

Brain NeoplasmsAppalachian RegionChildData CollectionHumansIncidenceKentuckyYoung AdultAppalachiaCancerCentral nervous systemKentuckyPediatric

Identifiers

PMID38056245
PMCPMC10842684
OpenAlexW4389333759

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.