Evidence map›Paper›PMID 38055970›Full record

ArticleBioconjugate chemistry2023

Solid-Phase Synthesis of Caged Luminescent Peptides via Side Chain Anchoring.

Daan Sondag, Jurriaan J A Heming, Dennis W P M Löwik, Elena Krivosheeva, Denise Lejeune, Mark van Geffen, Cornelis Van't Veer, Waander L van Heerde, Marjolijn C J Beens, Brian H M Kuijpers and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. On-Resin Assembly of Macrocyclic Inhibitors ofJournal of medicinal chemistry · 2025
    Article
  2. Synthesis of Caged Aminoluciferin Peptides.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Daan SondagInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
Jurriaan J A HemingInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
Dennis W P M LöwikInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0002-9284-837X
Elena KrivosheevaEnzyre BV, Novio Tech Campus, Transistorweg 5-i, Nijmegen 6534 AT, The Netherlands.ORCID 0000-0001-8499-4409
Denise LejeuneInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.
Mark van GeffenEnzyre BV, Novio Tech Campus, Transistorweg 5-i, Nijmegen 6534 AT, The Netherlands.ORCID 0000-0003-1748-0007
Cornelis Van't VeerEnzyre BV, Novio Tech Campus, Transistorweg 5-i, Nijmegen 6534 AT, The Netherlands.
Waander L van HeerdeEnzyre BV, Novio Tech Campus, Transistorweg 5-i, Nijmegen 6534 AT, The Netherlands.
Marjolijn C J BeensSymeres BV, Kerkenbos 1013, Nijmegen 6546 BB, The Netherlands.
Brian H M KuijpersSymeres BV, Kerkenbos 1013, Nijmegen 6546 BB, The Netherlands.
Thomas J BoltjeInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0001-9141-8784
Floris P J T RutjesInstitute for Molecules and Materials, Radboud University, Nijmegen 6525 AJ, The Netherlands.ORCID 0000-0003-1538-3852
Radboud University Nijmegen · NLFlevoziekenhuis · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The synthesis of caged luminescent peptide substrates remains challenging, especially when libraries of the substrates are required. Most currently available synthetic methods rely on a solution-phase approach, which is less suited for parallel synthesis purposes. We herein present a solid-phase peptide synthesis (SPPS) method for the synthesis of caged aminoluciferin peptides via side chain anchoring of the P

Indexed as

PeptidesSolid-Phase Synthesis TechniquesArginineLysinePeptide LibraryArginineLysinePeptide LibraryPeptides

Identifiers

PMID38055970
PMCPMC10739589
OpenAlexW4389367707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.