ArticleJournal of chemical information and modeling2023
HOMA Index Establishes Similarity to a Reference Molecule.
Article in Journal of chemical information and modeling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Aromaticity recovery as a driving force for electron transfer and radical addition in 5-hydroxy-1,4-naphthoquinone derivatives.RSC advances · 2026Article
- How to evaluate aromaticity under pressure? Benzene as a benchmark system.Chemical science · 2026Article
- Stabilization of the Benzene Radical Trianion in an Inverse-Sandwich Yttrium Complex.Angewandte Chemie (International ed. in English) · 2026Article
- Influence of Dimerization on Aromaticity in Benzene and Heteroaromatic Rings.The Journal of organic chemistry · 2026Article
- Unveiling the Interplay between Dopamine-like Molecules and β-Amyloid Peptide: A Combined Molecular Dynamic and DFT Approach.Combinatorial chemistry & high throughput screening · 2026Article
- On Diphenalenes Comprising Seven Hexagonal Rings.ACS omega · 2025Article
- Aromaticity of substituted 8-hydroxyquinolines in their free or bidentate states in tricarbonyl rhenium(i) complexes.RSC advances · 2025Article
- Imidazo[1,5-a]pyridines - A Versatile Platform for Structurally Distinct N-Heterocyclic Olefins and π-Extended Heterocycles.Angewandte Chemie (International ed. in English) · 2025Article
- The Form of the HOMA Geometric Aromaticity Index Is Universal and Allows the Design of Electronic and Magnetic Descriptors.The Journal of organic chemistry · 2025Article
- Utilization of a Chelating Bis[(dialkylamino)cyclopropenimine] to Isolate a Series of Heavier Zero-Valent Group 14 Tetracarbonyl Iron Complexes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Study of the Electronic Structure of Coronene Doped with Nitrogen Atoms and Its Effect on COACS omega · 2025Article
- HOMAc: A Parameterization of the Harmonic Oscillator Model of Aromaticity (HOMA) That Includes Antiaromaticity.The Journal of organic chemistry · 2025Article
- Organocatalytic enantioselective synthesis of double S-shaped quadruple helicene-like molecules.Nature communications · 2025Article
- Unveiling the Intermolecular Interactions between Drug 5-Fluorouracil and Watson-Crick/Hoogsteen Base Pairs: A Computational Analysis.ACS omega · 2024Article
- From π-conjugated macrocycles to heterocycloarenes based on benzo[2,1-Chemical science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The article shows that the definition of the HOMA index of geometrical aromaticity satisfies the axioms of a similarity function between the examined and benzene ring. Consequently, for purely mathematical reasons, the index works exceptionally well as an index of aromaticity: it expresses a geometric similarity to the archetypal aromatic benzene. Thus, if the molecule is geometrically similar to benzene, then it is also chemically similar, and therefore, it is aromatic. However, the similarity property legitimizes using the HOMA-like indices to express similarity to molecules other than benzene, whether cyclic or linear and existing or hypothetical. The paper demonstrates an example of HOMA-similarity to cyclohexane, which expresses a (relaxed)-saturicity property not accompanied by strong structural strains or steric hindrances. Further, it is also shown that the HOMA index can evaluate the properties of whole molecules, such as 25 unbranched catacondensed isomers of hexacene. The index exhibits a significant quadratic correlation with the total energy differences of planar isomers from which the nonplanar ones deviate. Moreover, the HOMA index of hexacene isomers significantly correlates with the Kekulé count connected to the resonance energy in the Hückel approximation. As a result, the study shows that the HOMA index can be used not only for aromaticity analyses but also as a general chemical descriptor applicable to rings, chains, composed molecular moieties, or even whole molecules.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.