Evidence map›Paper›PMID 38055837›Full record

ArticleJournal of tropical pediatrics2023

Evaluating blood culture collection practice in children hospitalized with acute illness at a tertiary hospital in Malawi.

Victoria Temwanani Mukhula, Philliness Prisca Harawa, Chisomo Phiri, Stanley Khoswe, Emmie Mbale, Caroline Tigoi, Judd L Walson, James A Berkley, Robert Bandsma, Pui-Ying Iroh Tam and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Victoria Temwanani MukhulaPaediatrics and Child Health Research Group, , Malawi-Liverpool Wellcome Research Programme P.O. Box 30096, Chichiri, Blantyre, Malawi.
Philliness Prisca HarawaPaediatrics and Child Health Research Group, , Malawi-Liverpool Wellcome Research Programme P.O. Box 30096, Chichiri, Blantyre, Malawi.
Chisomo PhiriThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
Stanley KhosweThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
Emmie MbaleDepartment of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi.
Caroline TigoiThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
Judd L WalsonThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
James A BerkleyThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
Robert BandsmaThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.
Pui-Ying Iroh TamPaediatrics and Child Health Research Group, , Malawi-Liverpool Wellcome Research Programme P.O. Box 30096, Chichiri, Blantyre, Malawi.ORCID 0000-0002-3682-8892
Wieger VoskuijlThe Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.ORCID 0000-0001-5825-2831
The Childhood Acute Illness and Nutrition Network · KEUniversity of Liverpool · GBEmma Kinderziekenhuis · NLKamuzu Central Hospital · MWUniversity of Oxford · GBUniversity of Toronto · CAUniversity of Washington · US

Funding

Bill & Melinda Gates Foundation OPP 1191165Wellcome Trust
6 · The paper itself

Abstract

backgroundBlood culture collection practice in low-resource settings where routine blood culture collection is available has not been previously described. METHODOLOGY: We conducted a secondary descriptive analysis of children aged 2-23 months enrolled in the Malawi Childhood Acute Illness and Nutrition (CHAIN) study, stratified by whether an admission blood culture had been undertaken and by nutritional status. Chi-square test was used to compare the differences between groups.

resultsA total of 347 children were included, of whom 161 (46%) had a blood culture collected. Children who had a blood culture collected, compared to those who did not, were more likely to present with sepsis (43% vs. 20%, p < 0.001), gastroenteritis (43% vs. 26%, p < 0.001), fever (86% vs. 73%, p = 0.004), and with poor feeding/weight loss (30% vs. 18%, p = 0.008). In addition, hospital stay in those who had a blood culture was, on average, 2 days longer (p = 0.019). No difference in mortality was observed between those who did and did not have a blood culture obtained.

conclusionBlood culture collection was more frequent in children with sepsis and gastroenteritis, but was not associated with mortality. In low-resource settings, developing criteria for blood culture based on risk factors rather than clinician judgement may better utilize the existing resources.

Indexed as

GastroenteritisSepsisAcute DiseaseBlood CultureChildHumansMalawiTertiary Care Centersantimicrobial resistanceblood culturebloodstream infectionchildrenmalnutrition

Identifiers

PMID38055837
PMCPMC10699738
OpenAlexW4389450303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.