Evidence map›Paper›PMID 38055781›Full record

ArticleeLife2023

Apoptotic signaling clears engineered

Taylor J Abele, Zachary P Billman, Lupeng Li, Carissa K Harvest, Alexia K Bryan, Gabrielle R Magalski, Joseph P Lopez, Heather N Larson, Xiao-Ming Yin, Edward A Miao

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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  5. Human non-canonical inflammasomes activate CASP3 to limit intracellularbioRxiv : the preprint server for biology · 2025
    Article
  6. Innate detection ofbioRxiv : the preprint server for biology · 2025
    Article
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  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Taylor J AbeleDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.ORCID 0000-0002-7910-3381
Zachary P BillmanDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.
Lupeng LiDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.
Carissa K HarvestDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.
Alexia K BryanDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.
Gabrielle R MagalskiDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Joseph P LopezDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, United States.
Heather N LarsonDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.
Xiao-Ming YinDepartment of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, United States.
Edward A MiaoDepartment of Integrative Immunobiology, Duke University School of Medicine, Durham, United States.ORCID 0000-0001-7295-3490
Duke University · USUniversity of North Carolina at Chapel Hill · USTulane University · US

Funding

Innate immune defenses against a cytosolic capsuleR01AI136920 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Edward A Miao · 2019 to 2026
$3.7M
Intestinal epithelial cell exfoliation by caspasesR01AI139304 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2M
Natural killer cell cytotoxicity against intracellular bacteriaR01AI133236 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2018 to 2022
$2.2M
Natural killer cell cytotoxicity against intracellular bacteriaR56AI133236 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, EDWARD A · 2017 to 2017
$291k
NIAID NIH HHS R01 AI133236NIAID NIH HHS R01 AI136920NIAID NIH HHS R01 AI139304NIAID NIH HHS R56 AI133236
6 · The paper itself

Abstract

Pyroptosis and apoptosis are two forms of regulated cell death that can defend against intracellular infection. When a cell fails to complete pyroptosis, backup pathways will initiate apoptosis. Here, we investigated the utility of apoptosis compared to pyroptosis in defense against an intracellular bacterial infection. We previously engineered

Indexed as

ApoptosisFlagellinAnimalsCaspase 1Cell DeathInflammasomesMicePyroptosisSalmonella typhimuriumCaspase 1FlagellinInflammasomesapoptosisextrusionimmunologyinfectious diseaseinflammationmicrobiologymousepyroptosisregulated cell deathSalmonella

Identifiers

PMID38055781
PMCPMC10699806
OpenAlexW4385799732

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.