Evidence map›Paper›PMID 38055674›Full record

ArticlePloS one2023

Involvement of an IgE/Mast cell/B cell amplification loop in abdominal aortic aneurysm progression.

Alexia Loste, Marc Clément, Sandrine Delbosc, Kevin Guedj, Jean Sénémaud, Anh-Thu Gaston, Marion Morvan, Guillaume Even, Grégory Gautier, Alexander Eggel and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 2 countries.

Alexia LosteUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Marc ClémentUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Sandrine DelboscUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Kevin GuedjUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Jean SénémaudUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Anh-Thu GastonUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Marion MorvanUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Guillaume EvenUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Grégory GautierDHU FIRE, Paris, France.
Alexander EggelDepartment for BioMedical Research, University of Bern, Bern, Switzerland.
Michel ArockDepartment of Biology and CNRS UMR8113, Ecole Normale Supérieure de Paris-Saclay, Saclay, France.
Emanuele ProcopioUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Catherine DeschildreUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Liliane LouedecUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Jean-Baptiste MichelUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Lydia DeschampsDepartment of Pathology, AP-HP, Bichat Hospital, Université Paris Cité, Paris, France.
Yves CastierINSERM UMRS 1149, Centre de Recherche sur l'Inflammation (CRI), Université Paris Cité, Paris, France.
Raphaël CoscasUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Jean-Marc AlsacDepartment of Vascular Surgery, AP-HP, Hôpital Européen Georges Pompidou, Université Paris Cité, Paris, France.
Pierre LaunayDHU FIRE, Paris, France.ORCID 0000-0002-3560-1389
Giuseppina CaligiuriUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Antonino NicolettiUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.
Marie Le BorgneUniversité Paris Cité and Université Sorbonne Paris Nord, INSERM, LVTS, Paris, France.ORCID 0000-0002-3439-4867
Inserm · FRUniversité Paris Cité · FRUniversity of Bern · CHCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsIgE type immunoglobulins and their specific effector cells, mast cells (MCs), are associated with abdominal aortic aneurysm (AAA) progression. In parallel, immunoglobulin-producing B cells, organised in tertiary lymphoid organs (TLOs) within the aortic wall, have also been linked to aneurysmal progression. We aimed at investigating the potential role and mechanism linking local MCs, TLO B cells, and IgE production in aneurysmal progression. METHODS AND

resultsThrough histological assays conducted on human surgical samples from AAA patients, we uncovered that activated MCs were enriched at sites of unhealed haematomas, due to subclinical aortic wall fissuring, in close proximity to adventitial IgE+ TLO B cells. Remarkably, in vitro the IgEs deriving from these samples enhanced MC production of IL-4, a cytokine which favors IgE class-switching and production by B cells. Finally, the role of MCs in aneurysmal progression was further analysed in vivo in ApoE-/- mice subjected to angiotensin II infusion aneurysm model, through MC-specific depletion after the establishment of dissecting aneurysms. MC-specific depletion improved intramural haematoma healing and reduced aneurysmal progression.

conclusionsOur data suggest that MC located close to aortic wall fissures are activated by adventitial TLO B cell-produced IgEs and participate to their own activation by providing support for further IgE synthesis through IL-4 production. By preventing prompt repair of aortic subclinical fissures, such a runaway MC activation loop could precipitate aneurysmal progression, suggesting that MC-targeting treatments may represent an interesting adjunctive therapy for reducing AAA progression.

Indexed as

Aortic Aneurysm, AbdominalMast CellsAngiotensin IIAnimalsAorta, AbdominalDisease Models, AnimalHumansImmunoglobulin EInterleukin-4MiceMice, Inbred C57BLMice, Knockout, ApoEAngiotensin IIImmunoglobulin EInterleukin-4

Identifiers

PMID38055674
PMCPMC10699626
OpenAlexW4389398669

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.