Evidence map›Paper›PMID 38055613›Full record

ArticleeLife2023

Sustained store-operated calcium entry utilizing activated chromatin state leads to instability in iTregs.

Huiyun Lyu, Guohua Yuan, Xinyi Liu, Xiaobo Wang, Shuang Geng, Tie Xia, Xuyu Zhou, Yinqing Li, Xiaoyu Hu, Yan Shi

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Causal association of gastroesophageal reflux disease with chronic sinusitis and chronic disease of the tonsils and adenoids.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Huiyun Lyu *Institute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.
Guohua Yuan *IDG/McGovern Institute for Brain Research and School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Xinyi LiuInstitute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.
Xiaobo WangInstitute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.
Shuang GengDepartment of Microbiology, Immunology and Infectious Diseases, Snyder Institute, University of Calgary, Calgary, Canada.
Tie XiaInstitute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.
Xuyu ZhouKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
Yinqing LiIDG/McGovern Institute for Brain Research and School of Pharmaceutical Sciences, Tsinghua University, Beijing, China.
Xiaoyu HuInstitute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.ORCID 0000-0002-4289-6998
Yan ShiInstitute for Immunology, Beijing Key Lab for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.ORCID 0000-0002-6715-7681
Tsinghua University · CNKing Center · USMcGovern Institute for Brain Research · USUniversity of Calgary · CAChinese Academy of Sciences · CN

Funding

CIHR PJT-156334CIHR PJT-166155
6 · The paper itself

Abstract

Thymus-originated tTregs and in vitro induced iTregs are subsets of regulatory T cells. While they share the capacity of immune suppression, their stabilities are different, with iTregs losing their phenotype upon stimulation or under inflammatory milieu. Epigenetic differences, particularly methylation state of

Indexed as

CalciumChromatinEpigenesis, GeneticForkhead Transcription FactorsSignal TransductionT-Lymphocytes, RegulatoryCalciumChromatinForkhead Transcription Factorscalcium signalchromatin accessibilitygeneticsgenomicsimmunologyinflammationiTregmouseNFATstabilityTreg

Identifiers

PMID38055613
PMCPMC10699804
OpenAlexW4383069268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.