Evidence map›Paper›PMID 38055397›Full record

ArticleActa cirurgica brasileira2023

WD repeat domain 5 promotes the development of late-onset preeclampsia by activating nuclear factor kappa B.

Xudong Zhao, Fengyun Su, Fanhua Kong, Juan Su, Xiaojing Yang, Lei Li, Aihua Li, Qinwen Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta cirurgica brasileira, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xudong ZhaoLiaocheng People's Hospital - Department of Obstetrics and Gynaecology - Liaocheng (Shandong Province) - China.ORCID http://orcid.org/0000-0001-5622-1716
Fengyun SuThe Second Affiliated Hospital of Shandong First Medical University - Second Affiliated Hospital - Department of Pharmacy - Taian City (Shandong Province) - China.ORCID http://orcid.org/0000-0002-0965-0080
Fanhua KongThe Affiliated Taian City Central Hospital of Qingdao University - Taian City Central Hospital - Departments of Thoracic Surgery - Taian City (Shandong Province) - China.ORCID http://orcid.org/0009-0007-1443-6269
Juan SuThe Affiliated Taian City Central Hospital of Qingdao University , Taian City Central Hospital - Department of Obstetrics and Gynecology Color Ultrasound - Taian City (Shandong Province) - China.ORCID http://orcid.org/0009-0003-3995-4725
Xiaojing YangThe Affiliated Taian City Central Hospital of Qingdao University - Taian City Central Hospital - Department of Obstetrics - Taian City (Shandong Province) - China.ORCID http://orcid.org/0009-0002-9212-2891
Lei LiShandong Provincial Hospital Affiliated to Shandong First Medical University - Shandong Provincial Hospital - Department of Obstetrics - Jinan City (Shandong Province) - China.ORCID http://orcid.org/0000-0002-3503-9445
Aihua LiLiaocheng People's Hospital - Department of Obstetrics and Gynaecology - Liaocheng (Shandong Province) - China.ORCID http://orcid.org/0000-0002-9480-4039
Qinwen LiThe Affiliated Taian City Central Hospital of Qingdao University - Taian City Central Hospital - Department of Obstetrics - Taian City (Shandong Province) - China.ORCID http://orcid.org/0009-0003-3472-9246
Qingdao University · CNAffiliated Hospital of Taishan Medical University · CNLiaocheng People's Hospital · CNShandong Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOver-activation of nuclear factor kappa B (NF-κB) was proven to be involved in the pathogenesis of preeclampsia. However, its regulation mechanism is not clear yet. This paper explored the role of WD repeat domain 5 (WDR5) in the development of late-onset preeclampsia and its relationship with NF-κB.

methodsWDR5 expression was detected in normal placentas and placentas from late-onset preeclampsia patients. CCK-8 and colony formation assays were conducted to appraise the proliferative ability of trophoblast. Migration and invasion were observed by wound healing and transwell assays. The interaction between WDR5 and NF-κB inhibitor I-kappa-B-alpha (IkBa) was verified by Co-immunoprecipitation analysis. Immunofluorescence was used to analyze the activation of NF-κB. Finally, we tested the role of WDR5 using the mice late-onset preeclampsia model.

resultsWDR5 was highly expressed in the placentas of late-onset preeclampsia patients. WDR5 overexpression suppressed cell proliferation, migration, and invasion in trophoblast. WDR5 could interact with IkBa to activate NF-κB. Knockdown of NF-κB counteracted the anti-proliferative and anti-metastatic effects of WDR5 overexpression in trophoblast. In-vivo studies suggested that targeting WDR5 combated late-onset preeclampsia development.

conclusionsOur finding provides new insights into the role of WDR5 in late-onset preeclampsia development.

Indexed as

NF-kappa BPre-EclampsiaAnimalsCell ProliferationFemaleHumansIntracellular Signaling Peptides and ProteinsMicePlacentaPregnancyTrophoblastsWD40 RepeatsIntracellular Signaling Peptides and ProteinsNF-kappa BWDR5 protein, human

Identifiers

PMID38055397
PMCPMC10691187
OpenAlexW4389222650

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.