Evidence map›Paper›PMID 38054722›Full record

ArticleMicrobiology spectrum2024

Vav proteins do not influence dengue virus replication but are associated with induction of phospho-ERK, IL-6, and viperin mRNA following DENV infection

Evangeline Cowell, Hawraa Jaber, Luke P Kris, Madeleine G Fitzgerald, Valeria M Sanders, Aidan J Norbury, Nicholas S Eyre, Jillian M Carr

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Evangeline CowellCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.
Hawraa JaberCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.
Luke P KrisCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.
Madeleine G FitzgeraldCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.
Valeria M SandersCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.
Aidan J NorburyFaculty of Health and Medical Sciences, University of Adelaide , Adelaide, South Australia, Australia.
Nicholas S EyreCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.ORCID 0000-0002-5424-7573
Jillian M CarrCollege of Medicine and Public Health and Flinders Health and Medical Research Institute, Flinders University , Bedford Park, Adelaide, South Australia, Australia.ORCID 0000-0002-1080-1472
Flinders University · AUThe University of Adelaide · AU

Funding

DHAC | National Health and Medical Research Council (NHMRC) GNT1183612Flinders Foundation Seed Grant
6 · The paper itself

Abstract

importanceDengue disease is characterized by an inflammatory-mediated immunopathology, with elevated levels of circulating factors including TNF-α and IL-6. If the damaging inflammatory pathways could be blocked without loss of antiviral responses or exacerbating viral replication, then this would be of potential therapeutic benefit. The study here has investigated the Vav guanine exchange factors as a potential alternative signaling pathway that may drive dengue virus (DENV)-induced inflammatory responses, with a focus on Vav1 and 2. While Vav proteins were positively associated with mRNA for inflammatory cytokines, blocking Vav signaling didn't affect DENV replication but prevented DENV-induction of p-ERK and enhanced IL-6 (inflammatory) and viperin (antiviral) mRNA. These initial data suggest that Vav proteins could be a target that does not compromise control of viral replication and should be investigated further for broader impact on host inflammatory responses, in settings such as antibody-dependent enhancement of infection and in different cell types.

Indexed as

DengueDengue VirusAntiviral AgentsHumansInterleukin-6RNA, MessengerVirus ReplicationAntiviral AgentsInterleukin-6RNA, Messengerazathioprinedengue virusinflammationinterleukin-6Vavviperin

Identifiers

PMID38054722
PMCPMC10782993
OpenAlexW4389397312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.