Evidence map›Paper›PMID 38054701›Full record

ArticleEnvironmental health perspectives2023

Associations of Prenatal Per- and Polyfluoroalkyl Substance (PFAS) Exposures with Offspring Adiposity and Body Composition at 16-20 Years of Age: Project Viva.

Mingyu Zhang, Sheryl L Rifas-Shiman, Izzuddin M Aris, Abby F Fleisch, Pi-I Debby Lin, Amy R Nichols, Emily Oken, Marie-France Hivert

Open access · diamondAbstract readComment
In one paragraph

Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
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  4. Stress-activated pathways mediate PFAS effects on human placental syncytiotrophoblast cells.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
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  8. Per- and polyfluoroalkyl substances (PFAS) toxicity and mitigation of adipogenic dysregulation in 3T3-L1 preadipocytes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Article
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  18. Cohort Profile Update: Project Viva Offspring.International journal of epidemiology · 2024
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Mingyu ZhangDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-3628-0983
Sheryl L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-0033-920X
Izzuddin M ArisDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0002-9239-7476
Abby F FleischCenter for Interdisciplinary Population Health Research, MaineHealth Institute for Research, Portland, Maine, USA.ORCID 0000-0002-2789-6412
Pi-I Debby LinDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-3564-4255
Amy R NicholsDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0002-3085-7377
Emily OkenDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0003-2513-3339
Marie-France HivertDepartment of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.ORCID 0000-0001-7752-2585
Harvard University · USBeth Israel Deaconess Medical Center · USMaineHealth · US

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
Prospective associations of childhood PFAS with metabolomic profiles, pubertal timing, and bone healthR01ES030101 · NIEHS · MAINEHEALTH · PI Abby Fleisch · 2019 to 2026
$3.6M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
NICHD NIH HHS R01 HD034568NIEHS NIH HHS R01 ES030101NIEHS NIH HHS R24 ES030894NIH HHS UG3 OD023286
6 · The paper itself

Abstract

backgroundFindings on the associations between prenatal PFAS exposures and offspring adiposity are inconsistent. Whether such associations may extend to adolescence is especially understudied.

objectivesWe investigated associations of prenatal PFAS exposures with offspring adiposity and body composition at 16-20 years of age.

methodsWe studied 545 mother-child pairs in the prospective prebirth cohort Project Viva (Boston, Massachusetts). We measured six PFAS (PFOA, PFOS, PFNA, PFHxS, EtFOSAA, and MeFOSAA) in maternal early pregnancy (

resultsThirteen percent ( DISCUSSION: Prenatal PFAS exposures may have obesogenic effects into late adolescence. https://doi.org/10.1289/EHP12597.

Indexed as

Alkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsAdiposityAdolescentBayes TheoremBody CompositionFemaleHumansMaleObesityPregnancyProspective StudiesAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbons

Identifiers

PMID38054701
PMCPMC10699168
OpenAlexW4389381270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.