Evidence map›Paper›PMID 38054412›Full record

ArticleJournal of clinical research in pediatric endocrinology2025

Worsening of Congenital Hypothyroidism After Start of Carob-bean Gum Thickened Formula: Is There a Link? A Case Report

Claudia Signorino, Giovanna Municchi, Marta Ferrari, Stefano Stagi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Claudia SignorinoUniversity of Florence Faculty of Medicine, Department of Health Sciences, Florence, ItalyORCID 0000-0002-7467-7781
Giovanna MunicchiMeyer Children’s Hospital IRCCS, Department of Pediatric Endocrinology, Florence, ItalyORCID 0009-0002-8662-3382
Marta FerrariMeyer Children’s Hospital IRCCS, Department of Pediatric Endocrinology, Florence, ItalyORCID 0000-0003-4858-4028
Stefano StagiUniversity of Florence Faculty of Medicine, Department of Health Sciences, Florence, ItalyORCID 0000-0002-2259-4685
Meyer Children's Hospital · ITUniversity of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital hypothyroidism (CH), if not correctly treated with levothyroxine (L-T4), may cause permanent intellectual disability. If patients treated with L-T4 do not achieve good thyroid stimulating hormone (TSH) control, the possibility of poor compliance and/or poor absorption of L-T4 should be investigated. We describe an infant with CH whose thyroid hormone levels worsened after she started a carob-bean gum thickened formula. A baby girl was diagnosed with CH by newborn screening [confirmatory venous blood TSH was 496.0 μIU/mL and free thyroxine (fT

Indexed as

Congenital HypothyroidismGalactansInfant FormulaMannansPlant GumsFemaleHumansInfant, NewbornThyroid Function TestsThyroxineGalactanslocust bean gumMannansPlant GumsThyroxinecarob-bean gum thickened formulacase reportCongenital hypothyroidismgastroesophageal refluxgastro-intestinal absorptionL-thyroxinetreatment

Identifiers

PMID38054412
PMCPMC12118310
OpenAlexW4389384057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.