Evidence map›Paper›PMID 38054290›Full record

ArticleCirculation. Cardiovascular imaging2023

Thoracic Aortic Calcium Density and Area in Long-Term Atherosclerotic Cardiovascular Disease Risk Among Men Versus Women.

Alexander C Razavi, Cherry Kim, Marly van Assen, Carlo N De Cecco, Daniel S Berman, Matthew J Budoff, Arshed A Quyyumi, Viola Vaccarino, Michael D Miedema, Khurram Nasir and 11 more

Open access · greenAbstract read
In one paragraph

Article in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 5 countries.

Alexander C Razavi *Emory Clinical Cardiovascular Research Institute (A.C.R., A.A.Q., V.V., L.S.S.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-3213-0876
Cherry Kim *Translational Laboratory for Cardiothoracic Imaging and Artificial Intelligence (A.C.R., C.K., M.v.A., C.N.D.C.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-3361-5496
Marly van AssenTranslational Laboratory for Cardiothoracic Imaging and Artificial Intelligence (A.C.R., C.K., M.v.A., C.N.D.C.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0003-4044-4426
Carlo N De CeccoTranslational Laboratory for Cardiothoracic Imaging and Artificial Intelligence (A.C.R., C.K., M.v.A., C.N.D.C.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-2956-3101
Daniel S BermanDepartment of Imaging, Cedars-Sinai Medical Center, Los Angeles, CA (D.S.B.).ORCID 0000-0002-3793-9578
Matthew J BudoffLundquist Institute, Harbor-University of California Los Angeles Medical Center, Torrance, CA (M.J. Budoff).ORCID 0000-0002-9616-1946
Arshed A QuyyumiEmory Clinical Cardiovascular Research Institute (A.C.R., A.A.Q., V.V., L.S.S.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-8166-679X
Viola VaccarinoEmory Clinical Cardiovascular Research Institute (A.C.R., A.A.Q., V.V., L.S.S.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-9054-0654
Michael D MiedemaMinneapolis Heart Institute and Foundation, MN (M.D.M.).ORCID 0000-0003-0499-5810
Khurram NasirDivision of Cardiovascular Prevention and Wellness, Houston Methodist DeBakey Heart and Vascular Center, TX (K.N.).ORCID 0000-0001-5376-2269
Alan RozanskiDivision of Cardiology, Mount Sinai, St. Luke's Hospital, New York, NY (A.R.).
Camilo FernandezDepartment of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA (C.F.).
John A RumbergerCorazon Imaging, Columbus, OH (J.A.R.).ORCID 0000-0001-5018-2832
Leslee J ShawCorazon Imaging, Columbus, OH (J.A.R.).ORCID 0000-0003-1268-1491
Martin Bødtker MortensenDepartment of Cardiology, Aarhus University Hospital, Denmark (M.B.M.).ORCID 0000-0003-2693-4154
Nathan D WongDepartment of Radiology, Weill Cornell Medicine, New York, NY (L.J.S.).ORCID 0000-0003-1102-7324
Roger S BlumenthalJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (R.S.B., S.P.W., M.J. Blaha, O.D.).ORCID 0000-0003-1910-3168
Laurence S SperlingEmory Clinical Cardiovascular Research Institute (A.C.R., A.A.Q., V.V., L.S.S.), Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-9417-6370
Seamus P WheltonJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (R.S.B., S.P.W., M.J. Blaha, O.D.).ORCID 0000-0001-5914-0735
Michael J BlahaJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (R.S.B., S.P.W., M.J. Blaha, O.D.).ORCID 0000-0001-5138-9683
Omar DzayeJohns Hopkins Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD (R.S.B., S.P.W., M.J. Blaha, O.D.).ORCID 0000-0001-9483-3510
Emory Healthcare · USJohns Hopkins University · USAmazon (United States) · USArtificial Intelligence in Medicine (Canada) · CAAarhus University Hospital · DKBrigham and Women's Hospital · USCedars-Sinai Medical Center · USEmory University Hospital · USHouston Methodist · USLos Angeles Biomedical Research Institute · USMinneapolis Heart Institute Foundation · USMount Sinai Hospital · USUniversity of California, Irvine · US

Funding

PATHOPHYSIOLOGY OF MYOCARDIAL DISEASEST32HL007227 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Chulan Kwon, WENDY S POST · 1985 to 2026
$21.2M
Translational Research Core - Engagement and Behavior ChangeP30DK111024 · NIDDK · EMORY UNIVERSITY · PI Mohammed Kumail Ali · 2016 to 2026
$13.4M
Multidisciplinary Research Training to Reduce Inequities in Cardiovascular HealthT32HL130025 · NHLBI · EMORY UNIVERSITY · PI Tené T Lewis, Viola Vaccarino · 2016 to 2026
$6.4M
NHLBI NIH HHS L30 HL110027NHLBI NIH HHS T32 HL007227NHLBI NIH HHS T32 HL130025NIDDK NIH HHS P30 DK111024
6 · The paper itself

Abstract

backgroundThe development of thoracic aortic calcium (TAC) temporally precedes coronary artery calcium more often in women versus men. Whether TAC density and area confer sex-specific differences in atherosclerotic cardiovascular disease (ASCVD) risk is unknown.

methodsWe studied 5317 primary prevention patients who underwent coronary artery calcium scoring on noncontrast cardiac gated computed tomography with TAC >0. The Agatston TAC score (Agatston units), density (Hounsfield units), and area (mm

resultsThe mean age was 60.7 years, 38% were women, and 163 ASCVD deaths occurred over a median of 11.7-year follow-up. Women had higher median TAC scores (97 versus 84 Agatston units;

conclusionsTAC density-area phenotypes do not consistently associate with ASCVD mortality though low TAC density relative to area may be a marker of increased ASCVD risk in women.

Indexed as

AtherosclerosisCardiovascular DiseasesCoronary Artery DiseaseVascular CalcificationCalciumFemaleHumansMaleMiddle AgedRisk AssessmentRisk FactorsCalciumcardiovascular diseasescoronary vesselsmortalitysex characteristicssmokers

Identifiers

PMID38054290
PMCPMC10841590
OpenAlexW4389391602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.