Evidence map›Paper›PMID 38054254›Full record

ArticleNMR in biomedicine2024

Probing human heart TCA cycle metabolism and response to glucose load using hyperpolarized [2-

Hsin-Yu Chen, Jeremy W Gordon, Nicholas Dwork, Brian T Chung, Andrew Riselli, Sanjay Sivalokanathan, Robert A Bok, James B Slater, Daniel B Vigneron, M Roselle Abraham and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Imaging of metabolic dysfunction in genetic cardiomyopathies.The international journal of cardiovascular imaging · 2025
    Review
  2. Hyperpolarized [1-Journal of magnetic resonance open · 2025
    Article
  3. Observational
  4. The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal.American journal of physiology. Endocrinology and metabolism · 2025
    Article
  5. Review
  6. HyperpolarizedNMR in biomedicine · 2024
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0002-2765-1685
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0003-2760-4886
Nicholas DworkDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Brian T ChungDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Andrew RiselliSchool of Pharmacy, University of California, San Francisco, California, USA.
Sanjay SivalokanathanDivision of Cardiology, University of California, San Francisco, California, USA.
Robert A BokDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
James B SlaterDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.
M Roselle AbrahamDivision of Cardiology, University of California, San Francisco, California, USA.
Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID 0000-0003-4183-3634
University of California, San Francisco · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUAN XU · 2011 to 2026
$19.9M
Hyperpolarized Carbon-13 Metabolic MRI of the Human HeartR33HL161816 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAM, MARIA ROSELLE, LARSON, PEDER ERIC ZUFALL · 2022 to 2023
$965k
NHLBI NIH HHS R33 HL161816NIBIB NIH HHS P41 EB013598NIH HHS P41EB013598NIH HHS R33HL161816
6 · The paper itself

Abstract

introductionThe healthy heart has remarkable metabolic flexibility that permits rapid switching between mitochondrial glucose oxidation and fatty acid oxidation to generate ATP. Loss of metabolic flexibility has been implicated in the genesis of contractile dysfunction seen in cardiomyopathy. Metabolic flexibility has been imaged in experimental models, using hyperpolarized (HP) [2-

methodsGood manufacturing practice [2-

resultsThe study protocol, which included HP substrate injection, MR scanning, and oral glucose load, was performed safely without adverse events. Key downstream metabolites of [2-

conclusionsHP [2-

Indexed as

MyocardiumPyruvic AcidAcetylcarnitineCarbon IsotopesGlucoseGlutamic AcidHumansLactatesMyocytes, CardiacAcetylcarnitineCarbon IsotopesGlucoseGlutamic AcidLactatesPyruvic Acidhyperpolarized 13C MRSmetabolismoral glucose load testpyruvateTCA cycle

Identifiers

PMID38054254
PMCPMC12532068
OpenAlexW4389397322

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.