Evidence map›Paper›PMID 38054242›Full record

ArticleChemical communications (Cambridge, England)2023

Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA

Ryuta Shioi, Lu Xiao, Linglan Fang, Eric T Kool

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical communications (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Fluorogenic Covalent Probes for RNA.Journal of the American Chemical Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryuta ShioiDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA. kool@stanford.edu.
Lu XiaoDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA. kool@stanford.edu.ORCID http://orcid.org/0000-0003-1934-4711
Linglan FangDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA. kool@stanford.edu.ORCID http://orcid.org/0000-0003-2637-090X
Eric T KoolDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA. kool@stanford.edu.ORCID http://orcid.org/0000-0002-7310-2935

Funding

Transcriptome Analysis with RNA-Reactive ProbesR35GM145357 · NIGMS · STANFORD UNIVERSITY · PI ERIC T. KOOL · 2022 to 2026
$3.0M
NIGMS NIH HHS R35 GM145357
6 · The paper itself

Abstract

Despite the broad utility of ketones in bioconjugation, few methods exist to introduce them into RNA. Here we develop highly reactive 2'-OH acylating reagents containing strained-ring ketones, and employ them as versatile labeling handles for RNA.

Indexed as

KetonesRNAAcylationIndicators and ReagentsIndicators and ReagentsKetonesRNA

Identifiers

PMID38054242
PMCPMC10745195

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.